E-钙粘蛋白在预测结直肠癌肝转移中的价值

Evaluation of E-cadherin in the prediction of liver metastasis of colorectal carcinoma

目的:检测E-钙粘蛋白(E-cad)在结直肠癌组织中的异常表达,探讨其与结直肠癌肝转移的关系。方法:应用免疫组化法检测无肝转移、同时性肝转移和异时性肝转移的各30例结直肠癌组织以及30例癌旁正常黏膜组织(对照组)中E-cad的异常表达情况。结果:(1)E-cad在结直肠癌组织中的异常表达显著高于癌旁正常黏膜组织(P<0.05);E-cad在结直肠癌组织中的异常表达与肿瘤浸润深度、淋巴结转移、Dukes分期等有关(P<0.05)。(2)E-cad在同时性和异时性肝转移组中的异常表达均显著高于无肝转移组(P<0.05)。结论:E-cad可能参与结直肠癌肝转移的生物学过程,其异常表达有可能作为高危患者术后肝转移的预测指标应用于临床。

Objective： To investigate the abnormal expression of E-cadherin in colorectal carcinoma and its correlation with liver metastasis of colorectal carcinoma. Methods： The abnormal expression of E- cadherin was detected using immunohistochemical methods in 30 colorectal carcinoma tissues without liver metastasis, 30 with synchronal liver metastasis, 30 with heterochronia liver metastasis and 30 surrounding normal colorectal tissues. Results： （1）The abnormal expression of E-cadherin in colorectal carcinoma was significantly higher than that in surrounding normal colorectal tissue （P〈0.05）; The abnormal expression of E-cadherin in colorectal carcinoma was related to depth of invasion, lymph node metastasis and Dukes stages（P〈0.05）. （2） The abnormal expression of E-cadherin in colorectal carcinoma with synchronal or heterochronia liver metastasis was significantly higher than that in tissues without liver metastasis （P〈0.05）. Conclusion： E-cadherin may play a role in the process of developing hepatic metastasis. The abnormal expression of E-cadherin in colorectal carcinoma may be considered as a new clinical indicator for monitor of hepatic metastasis and prognosis of colorectal carcinoma