正交试验法优选活络镇痛胶囊制备工艺的研究

Study on the Optimization of Preparative Technology of Huoluozhengtong Capsule with orthogonal Test

目的:优选活络镇痛胶囊中水提醇沉法的最佳提取工艺条件。方法:采用L9(34)正交试验法,以水煎次数、加水量、水煎时间、浓缩倍数、醇沉浓度为考察指标,每个因素设计3个水平。结果:最佳条件为水煎次数1次,加水量分别为9倍,水煎时间为5 h,最后浓缩倍数1:0.85,醇沉浓度70%。结论:本法是一种高选择性和高效率的提取活络镇痛胶囊有效成分方法。

Objective： To find out the optimization technological conditions for Huoluozhengtong capsule in subsiding alcohol method. Method： L9 （34 ） orthogonal test method was adopted, the times of water decocting, adding account of water, time of water decocting, times of concentration, concentration for alcohol subsiding were used as investigative targets, each of factors were designed three levels. Result： The optimization conditions were one times for water decocting, 9 times adding account of water, 5 hours for water decocting, times of concentration 1：0.85, 70% concentration of alcohol subsiding. Conclusion： The method has high selectivity and efficiency to extract effective components in Huoluozhengtong capsule.