输卵管妊娠与人乳头状瘤病毒感染相关性研究

A Study of Relationship between Tubal Pregnancy and Human Papillomavirus Infection

运用聚合酶链反应（PCR）技术，检测输卵管妊娠组和对照组人乳头状瘤病毒（HPV）DNA，并在光镜下行病理学检查。发现输卵管妊娠组HPVDNA阳性率为7／25，其中输卵管局部阳性6／25，宫颈分泌物和外周血阳性均为1／25；病检输卵管炎占80％（20／25）。对照组输卵管HPVDNA均阴性，输卵管炎仅1例。两组间均有显著差异（P＜0．05）。输卵管妊娠组中HPVDNA阳性者，输卵管蜕膜炎为3／17，阴性者为1／18，二者亦有显著差异（P＜0．05）。提示HPV感染与输卵管妊娠的发生密切相关。

Tubal pregnancy and control group were probed for HPV DNA with polymerase chain reaction (PCR) technique, and at the same time pathological examination was performed. Among the cases of tubal pregnancy, the HPV DNA positive rates of fallopian tube, villi, peripheral blood and cervical discharge were 16 % (4/25), 40 % (4/10), 4 % (1/25)and 4 % (1/25) respectively, The HPV infection rate was 28%(7/25) and the local infection rate of the tube was 24% (6/25). In the control group, the positive rate was zero. The difference was obviously significant (P<0. 05). The salpingitis was found in 80 % of the tubal pregnancy, while in the control group it was only 8%. Significant difference was observed (P<0.05). The decidualitis rate was 40 % in the tubal pregnancy HPV DNA positive group. There was significant difference (P<0.05) as compared with the incidence of the negative 6%. The results indicate that HPV infection is closely related to tubal pregnancy.