苯甲醛缩氨基硫脲与Cu^+、Co^(2+)、Ni^(2+)、Zn^(2+)、Mn^(2+)(SCN)_2配合物的抗癌活性研究Ⅱ

The second study of antitumor activities of Cu(Ⅰ),Co(Ⅱ),Ni(Ⅱ),Zn(Ⅱ),Mn(Ⅱ)(SCN) 2 complexes of benzaldehyde thiosemicarbazone

本文合成了苯甲醛缩氨基硫脲（ＨＬ）与铜、锌、钴、镍、锰离子的五个配合物。测试了五个配合物对Ｓ１８０腹水癌细胞的抗癌活性，发现Ｃｕ（ＨＬ）ＳＣＮ和Ｚｎ（ＨＬ）２（ＳＣＮ）２对癌细胞有强的杀伤作用，配合物Ｃｕ（ＨＬ）ＳＣＮ和Ｚｎ（ＨＬ）２（ＳＣＮ）２剂量分别为５ｍｇ／ｋｇ和１０ｍｇ／ｋｇ时，对Ｓ１８０荷瘤小鼠的存活时间延长率分别为５８．８２％和３８．２４％，对Ｓ１８０实体瘤的抑瘤率分别为７１．５７％和６７．０９％。

In this paper,5 complexes of benzaldehyde thiosemicarbazone (HL)with calts of Cu 2+ 、Zn 2+ 、Co 2+ 、Ni 2+ 、Mn 2+ were synthesized.The antitumor activities (Ertich cancer cell) of 5 complexes were evalu ated.We have found that the complexes Cu(HL)SCN and Zn(HL) 2(SCN) 2 exhibited antitumor activities.Prolonged rate of survival the time of tumor bearing Sarcoma 180 mice was 58.82% and 38.24%,when the dose of the complexes Cu(HL)SCN and Zn(HL) 2(SCN) 2 was 5 mg/kg and 10mg/kg.Inhibitory rate on tumor of tumor bearing Sarcoma 180 mice was 71.57% and 67.09%,when the dose of the complexes Cu(HL)SCN and Zn(HL) 2(SCN) 2 was 5mg/kg and 10mg/kg.