STAT5蛋白在非小细胞肺癌及正常肺组织中表达的对比研究

A Study on Expression of STAT5 in Non-Small Cell Lung Cancer and Normal Lung Tissues

目的探讨信号转导与转录激活因子5(signal transducers and activator of transcription 5,STAT5)在非小细胞肺癌及正常肺组织中的表达情况,分析STAT5的表达改变与非小细胞肺癌发生、发展的关系。方法应用SABC免疫组织化学技术检测47例非小细胞肺癌组织及15例正常肺组织中STAT5蛋白的表达。结果非小细胞肺癌组织中STAT5蛋白表达水平明显高于正常肺组织;STAT5蛋白表达水平与非小细胞肺癌组织学类型有关,在腺癌中的表达明显高于鳞癌;STAT5蛋白表达水平与肿瘤大小、组织分化程度、临床分期及淋巴结转移无关。结论STAT5蛋白的过度表达在非小细胞肺癌的发生、发展过程中可能起重要作用,此结果为目前肺癌诊断治疗的基础与临床研究提供了新的理论依据。

Objective To investigate the expressions of STAT5 （signal transducers and activator of transcription 5 ） in non-small cell lung cancer（NSCLC） and normal pulmonary tissues,and analyze the correlation between the changes of STAT5 expressions and occurrence and development of lung cancer. Methods 47 cases of NSCLC tissues were detected by immuno-histochemistry, with 15 cases of normal pulmonary tissues as control. Results There was significant difference of STAT5 expressions between NSCLC and normal pulmonary tissues; The level of STAT5 expressions is correlative with tissue reconstruction in NSCLC, which in adenocarcinomas was higher than squamous cell carcinomas, which is regardless with sex,age, tumor size,histodifferentiation level and lymphatic metastasis. Conclusions The over-expressions of STAT5 make an important role in occurrence and development of lung cancer. Thus it will offer an new theoretical foundation for research of basis and clinic in diagnose and therapy of lung cancer at present.