不同新辅助化疗方案对局部晚期宫颈癌的疗效观察

The Observation of Therapy Effect of the Different Neoadjuvant Chemotherapy on Locally Advanced Cervical Cancer

目的 探讨不同新辅助化疗方法 对局部晚期宫颈癌的疗效。方法 将我院2003年6月—2005年1月收治的Ⅰb2～Ⅱb期的局部晚期宫颈癌60例随机分为BIP方案组（博来霉素＋异环磷酰胺＋顺铂）、BVP方案组（博来霉素＋长春新碱＋顺铂）。对他们的有效率、毒副反应及2年复发率进行对比研究。结果 BIP方案组的有效率为86.7%，BVP方案组的有效率为80%，两组的有效率无明显差异；毒副反应BIP方案组小于BVP方案组；2年复发率BIP方案组低于BVP方案组。结论 在新辅助化疗中，BIP方案较BVP方案安全、有效。

Objective To discuss different chemotherapy programs of locally advanced cervical cancer （LACC）. Methods Divided 60 patients with LACC in stage Ⅰ b2 - Ⅱ b into two groups randomly：BIP （ BLM ＋ IFO ＋ DDP） group and BVP （ BLM ＋ VCR ＋ DDP）group, contrasted the effective rate,toxin and recrudesce rate. Results The effective rate of BIP and BVP were 86.7% and 80% respectively, they almost had the same effective rate. The toxin in the BIP group was lower than that in the BVP group, and the recurrent rate was lower in BIP group than that in BVP group, which showed significantly difference in the 2-year recurrent rate. Conclusions Neoadjuvant chemotherapy in the BIP group is safe and more effective than that in the BVP group.