摘要
目的观察FOLFOX4方案治疗晚期胃肠癌的近前疗效及不良反应。方法26例晚期胃肠癌患者采用FOLFOX4方案,即奥沙利铂(L-OHP)85mg/(m2.d),静脉滴注2h,第1天;CF 200mg/(m2.d)静脉滴注2h,第1,2天;5-FU 400mg/(m2.d),于CF滴完后静注,第1,2天,5-FU 600mg/(m2.d),微泵持续泵入22h,第1,2天。每2周重复,双周方案4周为1个周期。用2个周期以上者参加疗效评定。结果26例患者中CR3例(7.7%),PR10例(38.5%),SD9例(34.6%),PD4例(15.3%),总有效率(CR+PR)为46.2%。较明显的毒副反应为骨髓抑制、恶心、呕吐等胃肠道反应及末梢神经炎等,经对症处理,可以逆转。结论FOLFOX4方案治疗晚期胃肠癌,近期效率好,毒性反应可以耐受,是治疗晚期胃肠癌较理想的化疗方案,值得进一步应用和研究。
Objective To evaluate the efficacy and adverse effects of Oxaliplatin combined with 5-Fluouracil（5-FU） and calcium folinate in the treatment of patients with advanced gastrointestinal Tract cancer. Methods Twenty-six patients with advanced gastrointestinal tract canner received chemotherapy of regimen L-OHP 85 mg/m2 2 hours iv, D1, CF 200 mg/m^2 2 hours, iv,d1 d2 ,followed by 5-FU 400 mg/m^2 iv and 600 mg/m^2 22 hours civ dl d2 ,four weeks as one cycle,efficacy was evaluated after 2 cycle. Results 3 patients achieved complete response （ CR）, 10 patients partial response （ PR）, 9 patients stable disease （SD） ,4 patients progression disease（ PD）, Overall response rate was 46.2% , the major adverse effect reaction was bone suppression nausea/vomiting and peripheral never toxicity, all the side effects were tolerable and mild. Conclusions The regimen of FOLFOX4 is effective and tolerable for advanced gastrointestinal tract cancer.
出处
《实用全科医学》
2007年第10期851-852,共2页
Applied Journal Of General Practice
关键词
胃肠癌
奥沙利铂
亚叶酸钙
氟尿嘧啶
化疗
Gastrointestinal tract cancer
Oxaliplatin
Calcium folinate
5-Fluorouracil
Chemotherapy
