卵巢早衰患者自身免疫反应性指标的检测及其意义

Detection and analysis of autoimmunity data on patients of premature ovarian failure.

目的:检测卵巢早衰患者自身免疫反应状态,寻求有意义指标,为临床诊治提供指导。方法:49例卵巢早衰并不孕症患者为实验组,20例输卵管性不孕症患者为对照组,分别检查血清抗核抗体(antinuclear antibodies,ANA)、抗卵巢组织抗体(antiovarianantibodies,AOAb)、抗心磷脂抗体(Anticardiolipin,ACA)、抗甲状腺微粒体抗体(antithyroidmicrosomal antibodies,A-TG)、抗双链DNA抗体(ds-DNA)、免疫球蛋白(IgG,IgA,IgM,IgE)和补体(C3,C4)含量,并进行统计学分析。结果:实验组ANA、AOAb、ds-DNA、A-TG、C3阳性率分别为40.8%、42.9%、36.7%、46.9%和26.5%,均显著性高于对照组(P<0.05);试验组ACA、IgM异常率较高,分别30.6%、24.5%,但与对照组无显著差别(P>0.05);实验组IgG、IgA、IgE和C4异常率较低,分别为6.1%、2%、12%、4.1%,与对照组无显著差异(P>0.05)。结论:卵巢早衰患者有多种自身免疫性抗体,如ANA、AOAb、ds-DNA、A-TG、C3等,检测上述抗体对诊断自身免疫性卵巢早衰有临床意义。

Objective：To detect the autoimmunity data on the cases of premature ovarian failure （POF） for direction clinical diagnosis and management. Methods：Fifty-two patients diagnosed as POF associated with infertility and 20 cases of unexplained infertility were enrolled as the trial group and the control group respectively. The two groups were tested separately in the serum ANA, AOAb, ACA, A-TG, ds-DNA, IgG, IgA, IgM, IgE, and C3, C4. Results： The positive rates of ANA, AOAb, ds-DNA, A-TG, C3 in the trial group were 40. 8%, 42.9%, 36. 7% ,46.9% and 26.5% respectively ,which were significantly higher than those in the control group （P 〈0.05）. The abnormal rates of ACA and IgM were 30.6% and 24.5% in the trial group respectively ,which were higher than those in the control group but the difference was not significant （ P 〉 0.05 ）. The abnormal rates of IgG, IgA, IgE and C4 were 6.1% ,2% , 12% and 4.1% respectively, which were lower than those in the control group but there were no significant difference （ P 〉 0.05 ）. Conclusions： There are many kinds of autoimmune antibodies existing in the patients with POF. Testing of those significantly-increased antibodies, such as ANA, AOAb, ds-DNA, A-TG and C3, should be helpful for the diagnosis of POF.