美洛昔康缓释微囊的工艺研究与质量评价

Preparation and Evaluation of Meloxicam Microcapsule

目的:研究以明胶和阿拉伯胶为囊材,将美洛昔康微囊化的制备工艺。方法:以微囊的药物包封率为制备工艺优化指标,利用复凝聚法,通过正交实验得出微囊的最佳制备工艺条件。结果:囊材与囊心物的质量比2∶1,固化时间2 h、成囊pH4.0、成囊温度50℃为最佳工艺条件。结论:以最佳制备工艺条件制备含药微囊,重现性好,工艺稳定,同时体外溶出实验表明,该微囊具有较好的缓释作用。

Objective： To study the method to prepare Meloxicam microcapsule using gelatin-aracia gum as the sealing materials. Method： The orthogonal experimental design adopts the standard of drug encapsulation and optimizes the preparation procedure of the microcapsules by the complex coacervation method. Results： The result shows that proportion of the sealing material and core is 2： 1, the period of time is 2h, pH is 4.0, temperature is 50℃, which is the best technology. Conclusion： The characteristic of release is sustained- release