摘要
目的探讨终末期肾衰患者血液透析前后血红素氧化酶-1（HO-1）与白细胞介素-6（IL-6）、脂质过氧化物丙二醛（MDA）、同型半胱氨酸（Hcy）等指标的水平变化及相互之间的关系。方法自动生化分析仪测定血红蛋白、尿素氮、肌酐浓度;采用ELISA方法定量测定血清HO-1、IL-6,硫代硫巴比妥酸比色法测定MDA,荧光偏振法测定Hcy。结果终末期肾衰患者透析前HO-1、IL-6、MDA、Hcy水平明显升高,与对照组相比差异有统计学意义（P〈0.01）;血液透析治疗前后上述指标水平均有明显改变,血清HO-1水平较透前升高（P〈0.01）,IL-6、MDA、Hcy水平明显下降（P〈0.05）。结论血液透析能够提高终末期肾衰患者血清中HO-1水平,同时血液透析对IL-6、MDA、Hcy有一定的清除作用。
Objective To evaluate the effect of hemodialysis upon HO -1 ,IL- 6, Hcy level in ESRD patients pre -and post -henmodialysis. Methods The urea nitrogen and the blood creatinine level were estimated by automatic biochemistry analyzer ;HO - 1 ,IL- 6 level was measured by EHSA;MDA was measured by TBA;FPIA was used to quantitate Hcy. Results The HO - 1 ,IL -6,MDA,Hcy level in ESRD patients were up -regulated obviously compared with the control group;Mter the treatment of hemodialysis,the above index show up change evidently,HO- 1 value were up- regulated and IL-6,MDA,Hcy value were down- regulated significantly, Candusion Hemodialysis can elevate HO -1 level and lower IL-6,MDA,Hcy level in ESRD patients.
出处
《中原医刊》
2007年第16期6-8,共3页
Central Plains Medical Journal
