血管内皮生长因子和血小板衍生生长因子在子宫内膜癌中的表达及其与血管生成的关系

Expression of VEGF and PDGF, and its relation to angiogenesis in endometrial carcinoma

目的探讨子宫内膜癌中原癌基因血管内皮生长因子（VEGF）、血小板衍生生长因子（PDGF）的表达与临床病理参数和血管生成的关系。方法采用免疫组织化学的方法检测50例子宫内膜癌中VEGF、PDGF的表达,利用Ⅷ因子相关抗原标记血管内皮细胞,选择能代表肌层浸润深度的切片进行染色。结果子宫内膜癌中VEGF、PDGF的表达显著高于正常子宫内膜,VEGF的表达与临床分期、组织分化程度、肌层浸润深度显著相关。结论VEGF、PDGF可能通过诱导血管生成而促进子宫内膜癌的发生发展。

Objective To investigate the expression of vascular endothelial growth factor （VEGF） and platelet - derived endothelial cell growth factor （PDGF） and its relation to clinical pathological varible and angiogenesis in endometrial carcinoma. Methods A total of 50 specimens of endomerial carcinoma were evaluated by immunohistochemical techique with polyclonal antibody against VEGF and PDGF. Factor Ⅷ related antigen was used to detect endothelial cells. The deeptest myometrial invasion was selected for staining. Results VEGF and PDGF was significantly higher in EC than in normal endometrium, and was significantly correlated with clinical stage,grade and myometrial invasion. Conclusion The overexpression of VEGF and PDGF plays an important role in tumoregenisis and development of endometrial carcinoma.