急性脑梗死患者血中C-反应蛋白、D-二聚体水平的改变及葛根素干预研究

The changes of CRP,D - D content in blood after cerebral infarction and the therapeutic effect of puerarin on them

目的观察急性脑梗死（ACI）早期患者血中C-反应蛋白和D-二聚体含量的变化,并探讨葛根素治疗急性脑梗死的临床疗效和对C-反应蛋白和D-二聚体含量的影响。方法ACI患者64例,随机分为葛根素组（32例）（在常规治疗基础上加用葛根素）和常规治疗组（32例）。同时设立健康对照组30例。分别测定健康人和两组脑梗死患者治疗前后血中C-反应蛋白和D-二聚体含量。结果急性脑梗死早期患者血中C-反应蛋白和D-二聚体较健康人明显升高（P〈0.01）;治疗后葛根素组的D-二聚体较对照组明显降低（P〈0.05）;两组的C-反应蛋白含量差异无统计学意义（P〉0.05）;葛根素组治疗后的临床神经功能缺损评分（NIHSS,NDS）较对照组明显降低（P〈0.05）。结论急性脑梗死早期患者血中C-反应蛋白和D-二聚体含量较健康人明显升高;葛根素具有降低血中D-二聚体的作用,而对C-反应蛋白无影响;葛根素治疗急性脑梗死疗效显著。

Objective To observe the changes of C - reactive protein and D - dimer in blood after acute cerebral infarction （ACI）, And to evaluate the therapeutic effect of puerarin qn their changes. Methods Sixty - four cases with ACI were randomly divided into puerarin therapeutic group（Puerarin is used with general therapy） and general therapeutic group. CRP and D -D in blood after ACI were observed, while control group was set up. Results CRP and D - D content after ACI were all increased significantly（ P 〈0.01 ） ;the changes of D - D in puerarin therapeutic group was more significantly than that in general therapeutic group（ P 〈 0.05） ;The changes of CRP in both were not different significantly（ P 〉 0.05） ;NIHSS and NDS in puerarin therapeutic group reduced more significantly than in general therapeutic group （ P 〈 0.05 ）. Conclusion CRP and D - D content after ACI were all increased significantly; puerarin can reduce the content of D - D, but can not change the content of CRP; puerarin had significant therapeutic action on ACI.