老年高血压患者血浆抵抗素水平与胰岛素抵抗的相关性

Relationship of the Concentration of Serum Resistin and Insulin Resistance in the Elderly Hypertension Patients

目的了解老年高血压患者血浆抵抗素水平与胰岛素抵抗的关系。方法选择41例中青年人(对照组)和43例老年人(老年组),分别分为高血压组和正常血压组,用竞争性酶联免疫吸附试验测定各组空腹血浆抵抗素水平,同时测定空腹血糖、空腹胰岛素、血脂和胰岛素敏感指数,测量受试对象腰围、臀围和腰臀比。结果老年组血浆抵抗素水平与对照组相比明显升高(P<0.05),老年组中高血压亚组血浆抵抗素与正常血压亚组相比差异无显著性。对照组高血压亚组抵抗素水平略高于正常血压亚组,但差异无统计学意义(P>0.05)。抵抗素与年龄呈正相关(r=0.31,P<0.01;r=0.28,P<0.05),与体质指数呈正相关(r=0.23,P<0.05),与胰岛素抵抗指数呈负相关(r=-0.31,P<0.05),但在各实验组中,抵抗素与体质指数无明显相关性。结论空腹血浆抵抗素水平与年龄和体质指数呈正相关,与胰岛素抵抗指数呈负相关。

Aim To investigate the relationship of the concentration of serum resistin and insulin resistance in the elderly hypertension patients. Methods The patients （the young 41,the old 43） were divided into hypertension group and normal group. The concentration of fasting serum resistin was detected by enzyme linked immunosorbent assay （ELISA）, fasting blood sugar and insulin, serum lipid, and insulin sensitive index （ISI） were determined too, at the same time, waist circumstance,hip circumstance and waist haunch ratio （WHR） of the people involved were measured. Results The concentration of fasting serum resistin was significantly higher in the elder group than that in control group （P〈0.05）. There was no difference of serum resistin between the hypertension group and normal blood pressure group in the elder patients, and it was little higher in hypertension group than that of normal blood pressure in the control group but the difference was not significant （P〉0.05）. Plasma resistin was positively correlated with age （r=0.31,P〈0.01;r=0.28, P〈0.05）. The concentration of fasting serum resistin was positively correlated with body mass index （BMI） （r=0.23,P〈0.05）, negatively correlated with ISI （r=-0.31,P〈0.05）. But there were no significance between the concentration of resistin and BMI among the test groups. BMI, WHR, blood pressure, serum lipid, fasting serum sugar and insulin was not found to be related to the concentration of serum resistin. Conclusion Fasting plasma resistin was positively associated with age and BMI, but negatively associated with ISI.