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TSG-6研究进展 被引量：2

Study Progress of TSG-6
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摘要 TSG-6(TSG-6)基因是一个保护性的炎性反应性基因,在多种炎症性疾病或类似炎症的过程中呈高表达,通过与透明质酸、间-α-蛋白酶抑制剂结合介导炎性细胞的迁移、黏附,参与细胞外基质重塑,调节蛋白酶网络。在多种关节炎中,TSG-6具有使炎症局限,保护软骨的效果,另外,TSG-6还参与正常的排卵过程,并可能与肥胖的发生相关。 　TSG-6（tumor necrosis factor-stimulated gene-6,TSG-6） is a protective inflammatory reaction gene,which has high expression in many kinds of inflammatory diseases or processes similar to inflammatory,can mediate migration and adhesion of inflammatory cells by binding with hyaluronic acid and inter-α-proteinase inhibitor,take part in remodeling of extracellular matrix and regulate proteinase network.TSG-6 has effects of limiting inflammatory as well as protecting cartilage in kinds of arthritis.Besides that,TSG-6 also participates normal ovulation and maybe related to genesis of fatty.
作者 赵亚萍 郭锡熔 陈荣华
机构地区 解放军第 南京医科大学儿科医学研究所
出处 《医学综述》 2007年第18期1375-1377,共3页 Medical Recapitulate
关键词 TSG-6 透明质酸 间-α-蛋白酶抑制剂 关节炎 排卵 肥胖 Tumor necrosis factor-stimulated gene-6 Hyaluronic acid Inter-α-proteinase inhibitor Arthritis Ovulation Obesity
分类号 R392.11 [医药卫生—免疫学]
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参考文献25

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二级参考文献12

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共引文献10

同被引文献40

  • 1郑雪凌,王凤山,凌沛学.透明质酸合成酶的研究进展[J].药物生物技术,2004,11(6):413-416. 被引量：8
  • 2吴吉文,郑蔚颖,王玮.透明质酸对小鼠卵丘细胞外基质的影响[J].福建医科大学学报,2005,39(1):33-34. 被引量：3
  • 3Xu Y F, Li E L, Han Y L, Chen L, Xie Z. Differential expression of mRNAs encoding BMP/Smad pathway molecules in antral follicles of high-and low-fecundity Hu sheep. Animal Reproduction Scienee, 2010, 120: 47-55.
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医学综述
2007年 第18期

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