肠屏障功能的损伤与防护

Injury and Protection of Intestinal Barrier Function

肠屏障功能障碍是导致全身炎性反应综合征、多器官功能障碍综合征甚至多器官功能衰竭的一个重要因素。在饥饿、创伤、感染等应激状态下,肠屏障功能发生一系列的病理生理改变,导致肠黏膜细胞萎缩、通透性增加、肠道细菌移位。本文综述了影响肠屏障功能的因素,引起肠屏障功能损伤的机制及合理的营养支持途径、谷氨酰胺、生长激素及多肽类生长因子等因素对肠屏障功能的保护作用。

Intestinal barrier dysfunction is an important factor resulting in systemic inflamatory response syndrome（SIRS）、multiple organ dysfunction syndrome（MODS） and even the multiple organ failure（MOF）.In the stress state such as starvation,trauma,infection,the intestinal barrier function changes much in pathophysiology,and results in atrophy of intestinal mucosa cell,increase of intestinal permeability and bacterial translocation.Therefore,this text reviews the factors influencing intestinal barrier function,the mechanism of injury of intestinal barrier function,methods of rational nutritional support,and protection of glutamine,growth hormone,polypeptide growth factor for the intestinal barrier function.