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Apelin在心血管系统的研究进展 被引量:3

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摘要 Apelin是近年发现的一种重要的生理调节肽,起初它作为G蛋白偶联受体APJ的内源性配体受到研究者的重视,接着越来越多的证据表明它在心血管系统具有重要的生理和病理生理意义,本文就Apelin在心血管系统方面的研究进展做一综述。
作者 和亚萍 魏盟
出处 《国际心血管病杂志》 2007年第5期359-362,共4页 International Journal of Cardiovascular Disease
关键词 APELIN 心脏 血管 APJ
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参考文献20

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  • 2[2]Hosoya M,Kawamata Y,Fukusumi S,et al.Molecular and functional characteristics of APJ.Tissue distribution of mRNA and interaction with the endogenous ligand apelin[J].J Biol Chem,2000,275(28):21061-21067.
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  • 6[6]Medhurst AD,Jennings CA,Robbins MJ,et al.Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin[J].J Neurochem,2003,84(5):1162-1172.
  • 7[7]Iwanaga Y,Kihara Y,Takenaka H,et al.Down-regulation of cardiac apelin system in hypertrophied and failing hearts:Possible role of angiotensin Ⅱ-angiotensin type 1 receptor system[J].J Mol Cell Cardiol,2006,41(5):798-806.
  • 8[8]Ashley EA,Powers J,Chen M,et al.The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo[J].Cardiovasc Res,2005,65(1):73-82.
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