期刊文献+

SLE患者血清抗核小体抗体水平测定及意义 被引量:2

下载PDF
导出
摘要 采用酶联免疫吸附试验检测42例系统性红斑狼疮患者(SLE组)和30例健康人(对照组)血清抗核小体抗体(AnuA)水平。结果血清AnuA阳性率SLE组和对照组分别为69.04%和0(P<0.01);SLE活动期显著高于非活动期(P<0.01),有肾脏损害者明显高于无肾脏损害者(P<0.05);经泼尼松治疗后SLE组血清AnuA阳性率明显降低(P<0.05)。认为血清AnuA可能参与了SLE的发病机制;其可作为反映SLE活动程度、肾脏损害及预后的指标。
出处 《山东医药》 CAS 北大核心 2007年第23期61-62,共2页 Shandong Medical Journal
  • 相关文献

参考文献6

  • 1Kiss E,Lakos G,Nemeth J,et al.Significance of anti-nucleosome (anti-chromatin) auto-antibodies in systemic lupus erythematosus[J].Orv Hetil,2001,142(4):1731-1736.
  • 2Hochberg MC.Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J].Arthritis Rheum,1997,40(9):1725.
  • 3郑敏,朱铁城.SLE患者B淋巴细胞增殖功能测定及其临床意义[J].中华皮肤科杂志,1990,23(2):90-92. 被引量:35
  • 4Bombardier C,Gladaman DD,Urouritz MB,et al.Derivation of the SLEDAI.A disease activity index for lupus patients.The Cmmittee on Prognosis Studies in SLE[J].Arthritis Rheum,1992,35 (5):630-640.
  • 5Min DJ,Kim SJ,ParK SH,et al.Anti-nucleosome antibody:significance in lupus patients lacking antiduble stranded DNA antibody[J].Clin Exp Rheumatol,2002,20(2):13-18.
  • 6Cairns AP,McMillan SA,Crockard AD,et al.Antinucleosome antibodies in the diagnosis of systemic lupus erythematosus[J].AnnRheum Dis,2003,62(3):272-273.

二级参考文献1

  • 1杨锋,上海免疫学杂志,1987年,7卷,357页

共引文献34

同被引文献12

  • 1[1]Matsuyama W,Yanmoto M,Higashimoto I,et al.TNF related apoptosis inducing ligand is involved in neutropenia of systemic lupus erythematosus[J].Blood,2004,104(1):184-191.
  • 2[2]Komatsuda A,Wakui H,lwamoto K,et al.Up-regulation of TRAIL mBNA expression in peliphend blood mononuclear cells fmm patients with active systemic lupus erythematosus[J].Clinical Immunology.2007,125(1):26-29.
  • 3[3]Castellino G.Condlini F,Trottal F,et al.Elevatedlevels of TRAIL in systemic lupus erythematesus are associated to the prence of anti-SSA/SSB antibodies[J].Lupus,2007,16(7):479-482.
  • 4[4]Rus V,Zernetkinan V,Puliaev B et al.Increased expression and release of functional tumor necrosis factor-related apoptesis-inducing ligand(TRAIL)by T cells from lupus patients with active disease[J].Clin lmmunol,2005,117(1):48-56.
  • 5[5]Lub-de Hooge MN,de Vries EG,de Jong S,et al.Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus[J].Ann Rheum Dis,2005,64(6):854-858.
  • 6[7]Decker P,Singh-Jasuja H,Haager S.et al.Nucleosome,the main autoantlgen in systemic lupus rythematosus,induces direct dendritic cell activation via a MyD88-independent pathway:eonsequences on inflammation[J].J Immunol,2005,174(6):3326-3234.
  • 7[8]Bennett L,Palucka AK,Arce E,et al.Interferon and granulopoiesis signatures in systemic lupus erythematosus blood[J].J Exp Med,2003,197(6):711-723.
  • 8孙敏霞,吴纯,菅小红,董梅,匡铁吉.抗核小体抗体、抗Sm抗体、抗双链DNA抗体在系统性红斑狼疮诊断中的临床意义[J].中国实验诊断学,2007,11(8):1067-1068. 被引量:20
  • 9Premasany Kanapathippillaia, Annica Hedbergb, Chris G. Fentonc,Kristin A. Fentona1-J]. Nucleosomes contribute to increase mesangial cell chemokine expression during the de- velopment of lupus nephritis, 2013,2 (62) .. 244-252.
  • 10Hung WT, Chen YM, Lan JL, et al. Antinucleosome anti- bodies as a potential biomarker for the evaluation of renal pathological activity in patients with proliferative lupus ne- phritis[-J:. Lupus, 2011,20 (13) : 1404-1410.

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部