1[2]Pew Initiative on Biotechnology.Pharming in the Field:a look at the benefits and risks of bioengineering plants to produce pharmaceuticals.Washington:Pew Initiative on Food and Biotechnology,2003.
2[3]Mahoney P.T,Ramachandran S,and X Zu.The introduction of New vaccines into developing countriesⅡ.Vaccine financing.Vaccine,2000,18:2625-2635.
4[5]Rendi-Wagner P.Antibody-response to three recombinant hepatitis B Vaccine:connive Evaluation of Multicenter Travel-clinic based experience.Vaccine,2001,19:2055-2060.
5[6]Bosch FX,Manos MM,Munoz N,et al.Prevalence of human papillomavirus in cervical cancer:a worldwild perspective.International biological study on cervical cancer (IBSCC) Study Group.J Natl Cencer Inst,1995,87:796-802.
6[8]FDA Guidance for Industry:Environment Assessment of Human Drug and Biologics Application,1998.
7[9]ICH;Technical Requirements for Registration of Pharmaceuticals for Human Use Guidline S5B:Detection of Toxcity to Reproduction for Medicinal Products,2000.
5Lightowlers MW, Lawrence SB, Gauci CG, et al. Vaccination against hydatidosis using a defined recombinant antigen [J]. Parasite Immunol, 1996, 18 (9) :457-462.
6Lightowlers MW, Jensen O, Fernandez E, et al. Vaccination trials in Australia and Argentina confirm the effectiveness of the EG95 hydatid vaccine in sheep[J]. Int J Parasitol, 1999, 29(4) :531-534.
7Fu YC,Martinez C,Chalar C,et al. A new potent antigen from Echinococcus granulosus associated with muscles and tegument [J]. Mol Biochem Parasitol, 1999,102( 1 ) :43-52.
8Fu YC ,-Marchal S, Marchal T, et al. Cellular immune response of lymph nodes from dogs following the intradermal injection of a recombinant antigen corresponding to a 66kDa protein of Echinococcus granulosus[J]. Vet Immunol Immunopathol, 2000,74 (3-4) : 195-208.
9Riley EM, Dixon JB, Jenkins P, et al. Echinoeoceus granulosus infection in mice:host responses during primary and secondary infection [J]. Parasitol, 1986,92(2) : 391-403.
10Gottstein B, Mesarina B, Tanner I, et al. Specific cellular and humoral immune responses in patients with different long-term courses of alveolar echinococcosis [J]. Am J Trop Med Hyg, 1991,45(6) :734-742.
