连续性肾脏替代技术在创伤后急性肾功能衰竭治疗中的应用

Application of continuous renal replacement therapy in treatment of post-traumatic acute renal failure

目的探讨早期应用连续性肾脏替代技术（CRRT）治疗创伤后急性肾功能衰竭（ARF）的疗效和意义。方法回顾性分析102例行CRRT治疗的创伤后急性肾功能患者生存率和肾功能情况。结果102例接受CRRT治疗患者死亡50例，急性ARF发生24h内行CRRT患者32例，死亡8例；48h以上行CRRT患者47例，死亡32例，两者比较，差异有统计学意义（P〈0．01），CRRT有效降低肾脏负担并保持患者肾功能平稳。结论CRRT是救治创伤后急性ARF的有效方法，早期应用CRRT可能提高患者生存率。

Objective To investigate the clinical outcome of continuous renal replacement therapy （CRRT） for post-traumatic acute renal failure （ARF）. Methods The clinical data including the survival rate and renal function of 102 post-traumatic acute renal failure patients treated with CRRT were analyzed retrospectively. Results Of all, 50 patients died. Of 32 and 47 patients receiving CRRT within 24 and 48 hours of onset respectively, 8 and 32 died respectively, with statistical difference （P 〈 0. 01 ）. Renal function was efficiently improved after CRRT application and stabilized for a long term. Conclusion CRRT is an effective therapy for post-traumatic ARF. Early CRRT application can improve the survival rate.