Meta分析比较常规和超声引导下甲状腺细针穿刺细胞学检查对甲状腺结节的诊断价值

Diagnostic value of conventional and ultrasound-guided fine-needle aspiration biopsy for thyroid nodules:a Meta-analysis

目的:通过Meta分析来比较常规甲状腺细针穿刺细胞学检查(FNAB)、超声引导下FNAB对甲状腺结节的诊断价值。方法:检索PubMed和清华同方中国期刊网CNKI数据库关于甲状腺结节FNAB诊断相关的中英文文献,根据STARD的标准对文献进行评价和筛选。用Metadisc软件对纳入的试验结果进行合并。结果:甲状腺结节常规FNAB诊断共纳入8 801例,合并敏感度为84.9%,合并特异度为76.3%,加权SROC曲线下面积(AUC)为0.919 4。超声引导下FNAB诊断共纳入2 393例,合并敏感度为84.0%,合并特异度为80.8%,加权SROC曲线下面积(AUC)为0.935 6。结论:FNAB对甲状腺结节性质的诊断具有较高的准确性,而超声引导下FNAB比常规FNAB对甲状腺结节性质的诊断准确性更高。

Objective： To compare the diagnostic value of conventional fine needle aspiration biopsy（C-FNAB） and Ultrasound-guided FNAB（US-FNAB） for thyroid nodules by Meta-analysis. Methods： PubMed and CNKI database were searched for English and Chinese language articles related to FNAB diagnosis for thyroid nodules. The literatures were assessed and screened according to the Standards for Reporting of Diagnostic Accuracy （STARD）. Data were pooled by Metadisc software. Results： A total of 8 810 specimens were included in conventional FANA group and the pooled sensitivity,specificity, and the AUC of weighted summary receiver operating characteristic （SROC） curve were 84. 9%. 76. 3% and 0. 919 4, respectively; 2 393 specimens were included in US-FNAB group and the above numbers were 84.0%, 80.8% and 0. 935 6, respectively. Conclusion： FNAB has high accuracy in diagnosing thyroid nodules; the accuracy of ultrasound-guided FNAB is higher than conventional FNAB.