G-CSF的免疫调节作用及其在异基因造血干细胞移植中的应用

Effect of Granulocyte Colony-Stimulating Factor on Immunological Regulation and Its Application in Allogeniec Hematopoietic Stem Cell Transplantation——Review

粒细胞集落刺激因子(granuloctye colony-stimulating factor,G-CSF)在动员造血干细胞的过程中对体内多种免疫细胞的功能具有重要的调节作用,深入认识G-CSF的免疫调节作用对于减轻急性移植物抗宿主病(Graft-versus-host diseases,GVHD)的发生、维持和增强移植物抗白血病(Graft-versus-leukemia,GVL)效应以及降低造血干细胞移植患者的复发率等具有重要意义。本文就G-CSF对外周血及骨髓移植物的免疫调节作用、G-CSF的免疫调节作用与Allo-HSCT和细胞因子免疫调节作用的研究进行了综述。

The granulocyte colony-stimulating factor （G-CSF） plays an important role in regulating fumction of immunocytes in process of mobilizating hematopoietic stem cells. The deep understanding of the immunoregulatory effects of G-CSF has important significance to improve the outcomes of patients with hematological malignancies after allogeneic hematopoietic stem cell transplantation, included alleviating acute graft-versus-host disease, maintaining or enhancing graft-versus-leukmia effects and decreasing the relapse rates. In this article, the immunoregulatory effect of G-CSF on graft of peripheral blood and bone marrow, the immunoregulation of G-CSF and allo-hematopoietic stem cell transplantation, as well as the prospective trend of research on immunoregulatory effets of G-CSF were reviewed.