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游泳对慢性应激抑郁症模型大鼠行为学及脑内神经递质的影响 被引量:2

Effects of Swimming on Behavior and Monoamine Neurotransmitters in the Brain in Rat Model of Chronic Unpredictable Stress Depression
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摘要 方法:60只雄性SD大鼠,随机分为对照组(C)、运动组(E)、模型组(M)、运动应激组(ES)和运动应激运动组(ESE)。实验共14周。实验结束后,利用荧光分光光度法检测检测应激及游泳锻炼对单胺类神经递质含量的影响,探讨游泳锻炼预防抑郁的机制。结果:游泳锻炼能够升高应激状态下动物脑内NE、DA、5-HT的含量(P<0.01)。结论:游泳锻炼调节下丘脑组织中的DA、NE和海马组织中5-HT的含量可能是预防抑郁症的机制。 Methods : In this experiment, 60 SD male rats are devided into 5 groups at random : group C ( comparing group), group E (exercise), group M (model), group ES (exercise stress), and group ESE (exercise stress exercise). This experiment lasts 14weeks. After finishing the experiment, through fluorospectrophotometry, the author detects stress'and swimming's effect on quantity of monoamine neurotransmitter, and discusses the system to prevent depression by swimming. Result : In stress situation, swimming can increase the quality of NE, DA, and 5 - HT in animal brain. Conclusion: The system to prevent depression could be to cooperate the quality of NE as well as DA in hypothalamus and the quality of 5 - HT in hippocampus.
出处 《成都体育学院学报》 CSSCI 北大核心 2007年第5期96-99,共4页 Journal of Chengdu Sport University
关键词 单胺类神经递质 抑郁症 游泳锻炼 荧光分光光度法 monoamine neurotransmitter depression swimming training fluorospectrophotometry
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  • 1徐波,李群,孙晓英,吴国强.对我校研究生体质状况的测定研究[J].体育学刊,1999,6(5):54-55. 被引量:8
  • 2蔡定芳,沈自尹,张玲娟,陈晓红,堀口贞次郎,小岛晓,井上昌辉.右归饮对皮质酮大鼠下丘脑单胺类递质含量以及体重饮食摄水的影响[J].中国中西医结合杂志,1995,15(12):728-731. 被引量:22
  • 3庞志功,汪宝琪.液相色谱—化学发光联用技术对兔血浆中儿茶酚胺类物质的研究[J].西安医科大学学报,1995,16(3):282-283. 被引量:2
  • 4罗和春 周东丰 贾云奎 等.电针治疗抑郁症临床与实验研究[J].北京医科大学学报,1987,19:45-47.
  • 5[1]Engstrom G, Alling C, Blennow K, et al. Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters. Monoamine metabolites in 120 suicide attempters and 47 controls. Eur Neuropsy-chopharmacol, 1999,9(5): 399.
  • 6[2]Goodwin FK, Jamison KR. Manic-depressive illness. New York and Oxford: Oxford University Press, 1990. 416-447.
  • 7[3]Reddy PL, Khanna S, Subhash MN, et al. CSF amine netabolites in depression. Biol Psychiatry, 1992, 31(2): 112.
  • 8[4]Nordin C, Siwers B, Bertilsson L. Bromocriptine treatment of depressive disorders. Clinical and biochemical effects. Acta Psychiatr Scand, 1981,64(1): 25.
  • 9[5]BertilssonL, Tuck Jr, SiwersB. Biochemical effects of zimeldine in man.Eur J Clin Pharmacol, 1980, 18(5): 483.
  • 10[6]Peabody CA, Faull KF, King R J, et al. CSF amine metabolites and depression. Psychiatry Res, 1987, 21(5):1.

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  • 1郭慧荣,任玉明.乌灵菌粉治疗青少年适应障碍的效果及安全性[J].中国临床康复,2006,10(15):45-47. 被引量:5
  • 2刘卫,钱令嘉,杨志华,战锐,冯红,武磊.慢性温和应激抑郁模型大鼠5-羟色胺、色氨酸和应激激素的变化[J].中国应用生理学杂志,2006,22(2):169-172. 被引量:9
  • 3赵志宇,王卫星,郭洪祝,管振全,周东丰.甘草苷对慢性应激抑郁模型大鼠的抗抑郁作用[J].中国临床康复,2006,10(27):69-72. 被引量:59
  • 4Zhu W, Xie W, Pan T, et al. Comparison of neuroproteetive and neurorestorative capabilities of rasagiline andselegiline against laetaeystin-induced nigrostriatal dopaminergie degeneration [ J ]. J Neuroehem, 2008 [Epub ahead of print].
  • 5Gortzalez MM, Aston-Jones G. Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats[ J]. Proc Nail Acad Sci U S A,2008,105 (12) : 4898.
  • 6Won Jahng J,Khn NY, Ryu V,et al.Dexamethasone reduces food intake, weight gain and the hypothalamic 5-HTconcentration and increases plasma leptin in rats[J]. Eur J Pharmacol, 2/308,581 ( 1 - 2) :64.
  • 7Park SS, Schulz EM, Lee D. Disruption of dopamine homeostasis underlies selective neurodegeneration mediatedby alpha-synuclein [ J]. Eur J Neurosci, 2007,26(11) :3104.
  • 8李琳,王黎.针灸、放松功配合心理调适治疗中学生高考前焦虑、抑郁情绪31例[J].贵阳中医学院学报,2007,29(5):44-45. 被引量:9
  • 9Zalsman G,Brent DA,Weersing VR. Depressive disordersin childhood and adolescence: an overview: epidemiology,clinical manifestation and risk factors [J]. Child AdolescPsychiatr Clin N Am,2006,15(4) :827-841.
  • 10Gladstone TR,Beardslee WR,O'Connor EE. The preven-tion of adolescent depression [J]. Psychiatr Clin NorthAm,2011,34(l):35-52.

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