子痫前期患者胎盘组织中血小板内皮细胞黏附分子-1的表达

Expression of platelet endothlial cell adhesion molecule-1 in placenta of pre-eclampsia patients

目的：检测子痫前期患者和正常孕妇胎盘组织中血小板内皮细胞黏附分子-1（PECAM-1）的表达水平，探讨PECAM-1在子痫前期发病机制中的作用。方法：选取2005年5月～2006年5月在我院产科住院分娩病例80例，分为3组：轻度子痫前期组20例，重度子痫前期组30例，正常晚孕组（NT组）30例；胎盘组织中PECAM-1的表达水平采用免疫组化PV-9000法测定。结果：PECAM-1表达于胎盘绒毛血管内皮，重度子痫前期组同正常晚孕组比较，PECAM-1的表达水平降低（P〈0．05），轻度子痫前期组分别同正常晚孕组和重度子痫前期组比较，差异无统计学意义（P〉0．05）。结论：PECAM-1表达于胎盘绒毛血管内皮细胞上，在重度子痫前期患者中表达降低，且随病情的加重其表达水平不断降低。

Objective： The expressions of PECAM - 1 in the placenta tissue to elucidate its role in the etiology of pre - eclampsia. Methods： The subjects were divided into mild pre -eclampsia group （n = 20）, severe preeclampsia group （n = 30） and normal advanced pregnant group （n = 30） ; PV- 90（0 polymer detection system （immunohistochemistry） was applied to detect the expressions of PECAM- 1. Results： PECAM -1 expressed in the cytoplasm ofthe vessel endothelium of placental, which levels of severe pre - eclampsia group declines compared with that of the normal group （P 〈 0. 05 ）, while there was no statistical difference between mild and severe pre - eclampsia group and normal group （ P 〉 0. 05 ） . Conclusion： The level of PECAM - 1 expression is declined in severe pre - eclampsia patients, and it declines with the development of pre - eclampsia.