健胃愈疡片治疗消化性溃疡临床疗效与安全性观察

An Evaluation on Clinical Efficacy and Safety of Jianwei-Yuyang Tablets in the Treatment of Peptic Ulcer

目的：观察健胃愈疡片治疗消化性溃疡的临床疗效与安全性。方法：选择79例经确认的消化性溃疡患者，并采用中医辩证分型。观察每位用药者口服健胃愈疡片（1日4次，4-5片，次，共4周）前后的症状、体征及溃疡情况，评价疗效。结果：健胃愈疡片对消化性溃疡的主要证候胃脘痛、嗳气、返酸、嘈杂的有效率分别为：93．51％、90．00％、89．66％、87．10％；溃疡痊愈率为82．14％。对四种中医辩证分型证候的有效率：对肝郁脾虚的有效率为92．31％，对肝胃不和的有效率为90．63％，对脾胃虚寒有的效率为93．75％，对胃阴不足的有效率为80．00％。未发现与药物相关的不良反应。结论：健胃愈疡片治疗消化性溃疡疗效确切，安全可靠。

Objective：To observe the clinical efficacy and to evaluate the safety of Jianwei-Yuyang Tablets in the treatment of peptic ulcer. Methods： 79 patients who had been diagnosed as peptic ulcer and their aymptomatic types had been classified by the dialectical theory of Chinese traditional medicine were given Jianwei- Yuyang Tablets （4-5 patches, po, qid ） and the period lasted for four weeks. The curative effect of this medicine on peptic ulcer was observed and the safety was evaluated. Result：The efficiency rate of Jianwei-Yuyang Tablets was 82.14% on peptic ulcer. The recovery rate on main symptoms such as gastric abscess, belching, hyperchlorhydria and clatter was 93.51%, 90.00%, 89.66% and 87.10%, respectively. The rate of curative effect on depressed liver with the insufficient spleen, disharmony between the liver and stomach and insufficiency of the ＂spleen-yang＂ was 92.31%, 90.63% and 93.75%, respectively. No adverse events were observed. Condution： The Jianwei- Yuyang Tablets in the treatment of peptic ulcer are effective and safe in clinical practice.