耐甲氧西林溶血葡萄球菌耐药性监测

Surveillance on resistance of methicillin resistant staphylococcus haemolyticus infections

目的了解耐甲氧西林溶血葡萄球菌（MRSH）临床分布、对常用抗菌药物的耐药状况，指导临床用药。方法用Vitek-32系统对临床分离的120株溶血葡萄球菌（SH）进行菌种鉴定和药敏实验。结果临床分离凝固酶阴性葡萄球菌中SH占35．0％（120／343），SH中MRSH检出率为75．8％（91／120），MRSH对万古霉素、呋喃妥因100．0％敏感，对利福平敏感性高，对其余多种抗生素耐药率高。结论MRSH所致感染日趋严重，对多种抗生素耐药，临床应加强监测，MRSH感染的抗菌治疗应首选万古霉素。

Objective To investigate the clinical distribution and drug-resistance of methicillin resistant staphylococcus haemolyticus （MRSH） infection, and to provide the reference for the clinical antimierobial agents usage. Methods The identification and drug susceptibility tests were carried out with Vitek-32 for all the 120 strains of staphylococcus haemolyticus （SH） collected from our hospital. Results Totally 120 strains SH were isolated and MRSH accounted for 75.8% （91/120）, SH were 35.0M in 343 strains of coagulase negative staphylococcus （120/343）. MRSH were susceptible to vancomycin, nitrofurantoin and rifampin, while the rate of drug resistance to other antibiotics was all very high. Conclusion The incidence of MRSH infection has increased dramatically in recent years, which is resistant to many antibiotics. It may be important for clinical laboratories to identify isolates of MRSH routinely and to perform the antibiotic susceptibility tests. For treatment of the MRSH infection vancomycin can be used first.