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微小RNA与人类疾病的研究进展 被引量：1

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摘要 微小RNA（miRNA）是一类长约22nt的非蛋白编码RNA家族，它通过切割mRNA或者抑制翻译两种作用机制调控动植物生长发育。大量研究表明miRNA与人类疾病密切相关，其在肿瘤、心脏病、糖尿病和艾滋病等多种疾病中都起着重要作用。miRNA的深入研究，将有助于对生物体各种生理、病理机制的理解，并最终可能为疾病诊断和治疗提供新的思路和理论基础。
作者 眭维国 蓝慧娟 陈洁晶（综述） 戴勇 王应雄（审校）
机构地区 中国人民解放军第一八一医院中心实验室 广西师范大学生命科学学院 深圳市第一人民医院 重庆医科大学优生遗传教研室
出处 《国际检验医学杂志》 CAS 2007年第9期815-817,共3页 International Journal of Laboratory Medicine
关键词 微小RNA SIRNA 基因间隔区 RNA诱导沉默复合体
分类号 Q522 [生物学—生物化学]
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参考文献15

  • 1Gorodkin J, Havgaard JH, Enstero M, et al. MicroRNA sequence motifs reveal asymmetry between the stem arms [J]. Comput Biol Chem, 2006,30(4) :249-254.
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同被引文献17

  • 1He L,Thomson JM,Hemann MT,et al.A microRNA polycistron as a potential humanoncogene[J].Nature,2005,435(7043):828-833.
  • 2Wedel SA,Sparatore A,Soldato PD,et al.New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma[J].J Cell Mol Med,2008,12(6a):2457-2466.
  • 3Volinia S,Calin GA,Liu CG,et al.A microRNA expression signature of human solid tumors defines cancer gene targets[J].Proc Natl Acad Sci USA,2006,103(7):2257-2261.
  • 4Ambs S,Prueitt RL,Yi M,et al.Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer[J].Cancer Res,2008,68(15):6162-6170.
  • 5Sun R,Fu X,Li Y,et al.Global gene expression analysis reveals reduced abundance of putative microRNA targets in human prostate tumors[J].BMC Genomics,2009,10(1):93.
  • 6Porkka KP,Pfeiffer MJ,Waltering KK,et al.MicroRNA expression profiling in prostate cancer[J].Cancer Res,2007,67(13):6130-6135.
  • 7Saramaki OR,Porkka KP,Vessella RL,et al.Genetic aberrations in prostate cancer by microarray analysis[J].Int J Cancer,2006,119(6):1322-1329.
  • 8Ozen M,Creighton CJ,Ozdemir M,et al.Widespread deregulation of microRNA expression in human prostate cancer[J].Oncogene,2008,27(12):1788-1793.
  • 9Musiyenko A,Bitko V,Barik S.Ectopic expression of miR-126*,an intronic product of the vascular endothelial EGF-like 7 gene,regulates prostein translation and invasiveness of prostate cancer LNCaP cells[J].J Mol Med,2008,86(3):313-322.
  • 10Cimmino A,Calin GA,Fabbri M,et al.miR-15 and miR-16 induce apoptosis by targeting BCL2[J].Proc Natl Acad Sci USA,2005,102(39):13944-13949.

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国际检验医学杂志
2007年 第9期

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