摘要
由于临床分离的葡萄球菌对甲氧西林的耐药日益严重，其对临床抗感染治疗已形成严峻挑战，因此受到人们的广泛关注。近年来，随着分子生物学技术的不断发展特别是几株葡萄球菌全基因组测序的完成，葡萄球菌对甲氧西林耐药的分子机制的研究已逐步深入。现就葡萄球菌对甲氧西林耐药的调控机制的研究进展作一综述。
出处
《国际检验医学杂志》
CAS
2007年第9期821-823,共3页
International Journal of Laboratory Medicine
参考文献15
-
1Katayama Y, Ito T; Hiramatsu K. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus [J]. Antimicrob Agents Chemother, 2000, 44(6): 1549-1555.
-
2Ito T, Okuma K, Ma XX, et al. Insights on antibiotic resistance of Staphylococcus aureus from its whole genome: genomic island SCC [J]. Drug Resist Updat, 2003, 6(1): 41-52.
-
3Ito T, Katayama Y, Asada K, et al. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus [J]. Antimicrob Agents Chemother, 2001, 45(5): 1323-1336.
-
4Ito T, Ma XX, Takeuchi F, et al. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC [J]. Antimicrob Agents Chemother, 2004, 48 (7): 2637-2651.
-
5Ma XX, Ito T, Tiensasitorn C, et al. Novel type of staphylococcal cassette chromosome mec identified in community-acquired methicillin-resistant Staphylococcus aureus strains [J]. Antimicrob AgentsChemother, 2002, 46(4): 1147-1152.
-
6Berger-Bachi B, Rohrer S. Factors influencing methicillin resistance in staphylococci [J]. Arch Microbiol, 2002, 178(3): 165- 171.
-
7Pinho MG, de-Lencastre H, Tomasz A. An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci [J]. Proc Natl Acad Sci USA, 2001, 98(19) : 10886-10891.
-
8Wilke MS, Hills TL, Zhang HZ, et al. Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus [J]. J Biol Chem, 2004, 279(45): 47278-47287.
-
9Safo MK, Zhao Q, Ko TP, et al. Crystal structures of the BlaI repressor from Staphylococcus aureus and its complex with DNA: insights into transcriptional regulation of the bla and mec operons [J]. J Bacteriol, 2005, 187(5): 1833-1844.
-
10McKinney TK, Sharma VK, Craig WA, et al. Transcription of the gene mediating methicillin resistance in Staphylococcus aureus (mecA) is corepressed but not coinduced by cognate mecA and beta-lactamase regulators [J]. J Bacteriol, 2001, 183(23): 6862- 6868.
同被引文献12
-
1Brumfit W,Hamilion-Miller JMT.The world-wide prob-lem of methicillin resistant:staphylococcus aureus[J].Drugs Exp Clin Res,1990,16(5):205.
-
2Oliveira DC,de Lencastre H.Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant staphylococcus aureus[J].Antimicrob Anents Chemother,2002,46:2155-2161.
-
3Jeans D,Grundmann H,Hartung D,et al.Evaluation of the mecAfemB duplex polymerase chain reaction for detection of methicillin-resistant staphylococcus aureus[J].Eur J Clin Microbiol Infect Dis,1999,18:643-647.
-
4孙永华.耐甲氧西林金黄色葡萄球菌感染及对策[J].细菌耐药与抗感染研究进展(会议汇编),2006,6(昆明):10.
-
5Tenover FC,Arbeit RD,Goering RV,et al.Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis:criteria for bacterial strain typing[J].Clin Microbiol,1995,33(9),2233-2239.
-
6Ito T,Okuma K,Ma XX,Yuzawa H,et al.In sights on antibiotic resistance of staphylococcus aureus from its whole genomic island SCC[J].Drug Resist Update,2003,6:41-52.
-
7Ito T,Katayama Y,Asada K,et al.Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus[J].Antimicrob Agents Chemoth-er,2001,45:1323-1336.
-
8Ito T,Ma XX,Takeuchi F,et al.Novel type Ⅴ staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase,ccrC[J].Antimicrob A-gents Chemother,2004,48:2637-2651.
-
9Marcinak JF,Frank AL.Treatment of community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes:worldwide emer-gence[J].Emerging Infect Dis,2003,9:978-984.
-
10Johnson LB,Saravolatz LD.Community-acquired MRSA:Current epidemiology and management issues[J].Infect Med,2005,22:16-20.
-
1周义正,李向阳.葡萄球菌对甲氧西林耐药的调控机制[J].检验医学教育,2006,13(3):31-34.
-
2赵锐.细菌耐药性发生、发展与耐药机制[J].中国水电医学,2007,0(4):251-253. 被引量：3
-
3王同展.分子生物学技术在研究幽门螺杆菌中的应用[J].中国公共卫生,1995,11(4):183-185.
-
4顾米英,崔向阳,裴标.耐甲氧西林葡萄球菌的监测及控制[J].江苏预防医学,1999,10(1):47-48.
-
5黄钦,郭欣,徐凯建.耐甲氧西林金黄色葡萄球菌(MRSA)耐药性研究进展[J].中国药房,1997,8(3):135-136. 被引量：5
-
6童青,方莹.耐甲氧西林葡萄球菌耐药性分析[J].福建医药杂志,1998,20(4):118-120. 被引量：2
-
7赵惠敏.1997～2002年脑脊液耐甲氧西林葡萄球菌的监测[J].天坛药讯,2003,13(3):19-20. 被引量：2
-
8刘荣臻,史治国,陈建春,韩燕国,纪冰,张翠霞,谢志琴,和小华.耐甲氧西林金黄色葡萄球菌耐药性观察[J].中国实验诊断学,1999,3(5):244-245.
-
9居瑞雪,苏芬,倪光臻.金黄色葡萄球菌耐甲氧西林100株分析[J].中国误诊学杂志,2006,6(17):3388-3389. 被引量：1
-
10毕丽凤,徐倩,李洪志,陈洋.耐甲氧西林金黄色葡萄球菌三种检测方法的评价[J].中国误诊学杂志,2011,11(23):5636-5636.
