4-溴-3,5-二甲氧基苯甲醛的合成与表征

Synthesis and structural characterization of 4-bromo-3,5-dimethoxybenzaldehyde

以3,5-二羟基苯甲酸作为原料,经过溴化、甲基化、缩合、氧化等四步反应合成了4-溴-3,5-二甲氧基苯甲醛,其总收率为18.3%。该化合物作为前体化合物,可继续研究,合成溴莫普林。目标化合物结构经1H NMR和MS等表征。

Using 3,5-dihydroxybenzoic acid as the reactant,4-bromo-3,5-dimethoxybenzaldehyde was prepared by four steps reaction, including bromization,methylation, condensation and oxidation, and the total yield was 18.3%. As preceding compound,4-bromo-3,5-dimethoxybenzalde could study and synthesize brodimoprim. The structure of the title compound was confirmed by ^1H NMR, MS.