^(14)C尿素呼气试验诊断儿童幽门螺杆菌感染的临床评价

Clinical Evaluation of ^(14)C-Urea Breath Test for Diagnoisis of Helicobacter pylore Infection in Children

目的探讨14C尿素呼气试验(14C-UBT)对儿童幽门螺杆菌(Hp)感染的临床诊断价值。方法对76例有消化道症状患儿进行胃镜检查,同时采用胃黏膜组织学检查、快速尿素酶检测(RUT法)及14C-UBT进行Hp检测,并对3种方法进行比较。结果胃黏膜组织学检查、RUT法及14C-UBT检测Hp阳性率分别为42.1%,44.7%及44.7%,3种方法检出率无显著差异。以组织学检查结果为对照,14C-UBT与RUT法的敏感性分别为93.8%和90.6%,特异性为90.9%和88.6%,准确性为92.1%和89.5%,阳性预测值为88.2%和85.3%,阴性预测值为95.2%和92.9%。结论14C-UBT具有高度敏感性,是确诊儿童Hp感染的一种简便、快速、准确、无创安全且重复性好的方法。

Objective To evaluate ^14C-urea breath test for clinical （H. priori） infection in children. Methods 76 pediatric patients with diagnosis of Helicobacter pylorl dyspeptic symptoms undergoing gastroscopy were enrolled. ^14C-UBT was performed and comparatively evaluated with histology data and rapid urease test（RUT） for H. pylori diagnosis. Results H. pylori infection was detected postively by histology examination, RUT, or ^14C-UBT in 42.1%, 44.7%, and 44.7% of patients, respectively.^14C-UBT was comparable to histology and RUT with no significant difference in detection of H. priori infection. Compare with histology examination results, ^14C-UBT and RUT met an sensitivitic of 93.8% and 90.6%, specificity of 90.9% and 88.6% ,accuracy of 92.1% and 89.5%, positive predictive values of 88.2% and 85. 3%, negative predictive values of 95.2% and 92. 9%, respectively. Conclusions ^14C- UBT is a simple, rapid, safe highly sensitive and reliable method for accurate diagnosis of H. priori infectiong in children.