2Kisliuk RL.Deaza analogs of folic acid as antitumor agents[J].Curr Pharm Des,2003,9(31):2 615.
3Talyor EC,Liu B.A new and efficient synthesis of pyrrolo[2,3-d]pyrimidine anticancer agents:Alimta (LY231514,MTA),Homo-Alimta,TNP-351,and some aryl 5-substituted pyrrolo[2,3-d]pyrimidines[J].J Org Chem,2003,68(26):9 938.
4Gangje A,Zeng Y,McGuire JJ,et al.Synthesis of N-[4-[1-Ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-gl utamic acid as an antifolate[J].J Med Chem,2002,45(9):1 942.
5Hanauske AR,Chen V,Paolletti P,et al.Pemetrexed disodium:a novel antifolate clinically active against multiple solid tumors[J].Oncologist,2001,6(4):363.
6Gangjee A,Zeng Y,McGuire JJ,et al.Synthesis of classical,three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates[J].J Med Chem,2004,47(27):6 893.
7Gangjee A,Yang J,McGuireb JJ,et al.Synthesis and evaluation of a classical 2,4-diamino-5-substitutedfuro[2,3-d]pyrimidine and 2-amino-4-oxo-6-substitutedpyrrolo[2,3-d]pyrimidine as antifolates[J].Bioorg Med Chem,2006,14(24):8 590.
8Gangjee A,Lin X,Kisliuk RL,et al.Synthesis of N-4-[(2,4 diamino-5-methyl-4,7-dihydro3H-pyrrolo[2,3-d]pyrimidin-6-yl) thio]benzoyl-L-glutamic acid and N-4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6 -yl) thio]benzoyl-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents[J].J Med Chem,2005,48(23):7 215.
9Gangjee A,Jain DH,Phan J,et al.Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents:design,synthesis,and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates[J].J Med Chem,2006,49 (3):1 055.
10McGuire JJ.Anticancer antifolates:current status and future directions[J].Curr Pharm Des,2003,9 (31):2 593.