林下参总皂苷对高血糖大鼠的影响

Effects of Total Ginsenoside of Ginseng under Forest on Streptozocin-Induced Hyperglycemic Rats

目的观察林下参总皂苷(TGGUF)不同剂量组对高血糖大鼠血糖、体重、进食量、饮水量的影响。方法将正常Wistar大鼠腹腔注射0.054g/kg链脲霉素(STZ),造高血糖模型,并随机分为:模型组、消渴丸组、TGGUF高剂量组(0.40g/kg)、TGGUF中剂量组(0.20g/kg)和TGGUF低剂量组(0.10g/kg)。每日灌胃给药1次,每天记录各组大鼠的进食量和饮水量,连续给药4周,每周测空腹血糖、称体重各1次。结果TGGUF高剂量组可使高血糖大鼠血糖水平下降,抑制体重下降,进食量和饮水量减少,与模型组比较差异显著(P<0.05);TGGUF中剂量组可使高血糖大鼠血糖下降、饮水量减少,与模型组比较差异显著(P<0.05)。结论林下参总皂苷可使高血糖大鼠的血糖水平下降、体重增长、进食量和饮水量减少。

Objective To investigate the effects of total ginsenoside of ginseng under forest （TGGUF） at different doses on the hyperglycemic rats by analyzing the blood glucose, body weight, food and water intake. Methods The normal rats were ip. STZ （0.054g/kg） to make the hyperglycemia model. The hyperglycemic rats were administered TGGUF ig. at three doses （0.40g/kg, 0.20g/kg,0.10g/kg） once a day for four weeks. The food and water intake were recorded every day. The body weight and the blood glucose were recorded every week. Results The high and middle doses of the drug could reduce the blood glucose, food and water intake, at the same time, increase the body weight distinctively compared with model group （P〈0.05）. Conclusion TGGUF had the hypoglycemic effect on streptozocin-induced hyperglycemic rats.