大剂量皮质激素治疗婴幼儿血管瘤

Treatment of proliferative hemangiomas with high dose of systemic corticosteroid

目的:探讨大剂量皮质激素治疗婴幼儿增生期血管瘤的疗效及其并发症。方法:80例患儿服用泼尼松,前1～8周按4mg/kg给药,第9周减量为2片,第10周为1片,均隔日早晨8～9时口服,1个疗程10周,分析其治疗效果、疗程次数及近远期并发症。结果:皮质激素对增生期血管瘤治疗有效率为90%,92%的患儿经过1～2个疗程的治疗已提前进入消退期,没有发生严重的近、远期并发症。结论:1～2个疗程的激素治疗婴幼儿增生期血管瘤安全、有效,是值得推荐的一线治疗方法。

Objective：To investigate the efficacy and complication of high dose of corticosteroid in treatment of proliferative hemangiomas of infants.Methods：The proliferative hemangioma infants were administered prednisone in the first 8 weeks according to their wight（4 mg/kg）and the dosage was decreased to 2 tablets in the 9th week and 1 tablet in the 10th week;the medicine was taken orally once every two days at 8-9 am for 10 weeks.The outcome of treatment,courses of therapy,and short and long term of side effects were analyzed.Results：The overall response rate was 90% in proliferative hemangiomas infants treated with Corticosteroid;92% of the infants entered into stable involuting stage with no serious short or long term complications after 1-2 courses.Conclusions：1-2 courses of high dose of corticosteroids provide a safe and effective modality for treatment of proliferative hemangiomas in infants.It is worth popularizing.