高血压肾损害早期血、尿β_2-微球蛋白测定的临床意义

Clinical significance of blood and urine β_2-microglobulin determine in the early stage of hypertensive renal damage

目的:探讨血、尿β2-微球蛋白(β2-MG)对高血压肾病早期诊断和预防的意义。方法:对101例高血压患者行血、尿β2-MG(放射免疫法)、血清肌酐(sCr)测定(酶法),并根据CoCK-Croft-Gualt公式计数内生肌酐清除率(cCr),依据sCr分成A、B、C组比较。结果:B、C组患者Ccr均明显低于A组(P<0.01),而血、尿β2-MG均明显高于A组(P<0.05～P<0.01);对照组血β2-MG均明显低于A、B、C组(P<0.01),而尿β2-MG则明显低于B、C组(P<0.01)。结论:检测血、尿β2-MG对高血压肾损害早期诊断及预防有重要意义。

Objective：To investigate the value of blood and urine β2-microglobulin（β2-MG）in the early stage of hypertensive renal damage.Methods：The blood and urine β2-MG,as well as the serum creatinine（sCr）of 101 hypertension patients were detected by radioimmunity and enzymic method respectively.The creatinine clearance was calculated by CoCK-Croft-Gualt and the results were compared between the groups.Results：The Ccr of group B and C was obviously lower than that of group A（P〈0.01）,but the urine β2-MG of the two groups was obviously higher than that of group A（P〈0.05-P〈0.01）;Blood β2-MG of the control group was significantly lower than that of group A,B and C（P〈0.01）and its urine β2-MG was lower than that of group B and C significantly（P〈0.01）.Conclusions：It is of great diagnostic and prevent significance to detect the blood and urine β2-MG in patients with early renal damage caused by hypertension.