早期预防性光疗对早产儿高胆红素血症的干预

Effect of early prophylaxis phototherapy in premature infant hyperbilirubinemia

目的:评价早期预防性光疗干预对早产儿黄疸的影响。方法:对2004～2005年出生后24h内入院的39例早产儿(干预组),无论有无黄疸都进行预防性光疗,测定血清胆红素并观察其峰值,与2001年11月～2003年11月出生后24h内入院的41例未进行早期预防性光疗的早产儿(对照组)高胆红素血症发生率和血清胆红素峰值进行比较。结果:干预组和对照组高胆红素血症发生率分别为10.26%和51.22%,差异有统计学意义(P<0.005);干预组血清胆红素峰值(148.1±50.5)μmol/L显著低于对照组(222.2±62.5)μmol/L(P<0.001)。结论:对生后24h内的早产儿早期进行预防性光疗可防止高胆红素血症的发生。

Objective：To evaluate the effects of early prophylaxis phototherapy on hyperbilirubinemia in premature infants.Methods：Thirty-nine premature infants who were hospitalized in 24 h（intervention group）were born between Jan 2004 and Dec 2005.All the infants were treated by phototherapy regardless with or without hyperbilirubinemia and the serum bilirubin level was tested and the peak level was compared with the 41 premature infants who were hospitalized in the 24 h（control group）between Nov 2001 to Nov 2003 and were not treated by phototherapy.Results：The morbidity of intervention group and control group was 10.26% and 51.22% respectively with very significant difference（P〈0.005）.The serum bilirubin peak level in the intervention group（148.1±50.5）μmol/L was significantly lower than in the control group（222.2±62.5）μmol/L with very significant difference（P〈0.001）.Conclusions：Early prophylaxis phototherapy on 24 h premature infants may prevent hyperbilirubinemia.