氨基胍对糖尿病大鼠任意尿Pr/Cr比值和感染率的影响

Effects of aminoguaniding onthe random urinary Pr/Cr ratio and the rate of infectionin diabetic rats

本文对４０只用链脲菌素诱导的糖尿病大鼠进行适当控制，对比观察氨基胍和胰岛素对糖尿病大鼠任意尿蛋白／肌酐（Ｐｒ／Ｃｒ）比值的影响。结果表明与胰岛素相比，氨基胍能明显降低任意尿Ｐｒ／Ｃｒ比值。提示氨基胍对糖尿病的访治有重要意义。同时本文还发现氨基胍能降低糖尿病大鼠感染率。

In 40 streptozotocin - induced diabetic rata, the effect of aminoguanidine on random urinary pro- tein/creatinine (Pr/Cr) ratio was compared with that of insulin. It was found that the Pr/Cr ratio was significantly lower in the diabetic rats treated with aminoguanidine and insulin as compared with those treated with insulin alone, suggesting that aminoguanidine can prevent the development of diabetic nephropathy.At the same time ,the rate of infection i. aminoguanidine - treated group was also significantly lowered, suggesting that aminoguanidine or advanced glycosylation end - products can affect the immune function of diabetic rats.