谷胱甘肽S转移酶π在人肺癌组织的表达

Expression of GST-π in tumor tissue ofpatients with lung cancer

采用ＡＢＣ免疫组织化学染色法检测３０例肺癌（ＬＣ），３例良性肺部疾病（ＢＰＤ）和正常人（ＮＣ）肺组织中ＧＳＴ－π的表达。结果显示ＧＳＴ－π在肺癌组织阳性率为６６．７％，其中肺鳞癌，肺腺癌阳性率分别为８７．５％和６６．７％；大细胞癌和小细胞未分化癌（ＳＣＬＣ）均呈阴性染色：１０％癌旁正常肺组织呈弱阳性表达，正常及良性疾病肺组织均呈阴性势色。腺癌的表达与其不分化程度有关即高分化高表达。提示ＧＳＴ－π水平变化对非小细胞肺癌特别是肺鳞癌，腺癌有价值的标记物。

The levels of Glutathione S-transferase Pi(GST-π)isoenzyme were measured by ABC-immunohistoche-mical methods in human lung tissue from 30 patients with lung cancer(LC),30 patients with benign pulmonarydiseases(BPD)and normal controls(NC)Results:the positive staining rate of GST-πin patients with LC was66.7%,amony which,the positive rate with sgyamous(AC)were 87.5% and 66.7% respectively All cases withlarge cell carcinomas (SCC)and adenocarcinomas cell carcinoma (LCC)and small cell lung cancer(SCLC)werenegative staining,3 of 30 the cases (10%)in side-tumor lung tissue were shown weak positive staining.no caseswere found positive staining the lung tissue of normal and BPD groups However,the intensity of GST-π stainingappeared to be dpendent on the differentiation grade of AC,The well-differentiated of AC expressed highGST-π.Conclusions:the levels of GST-π may be available marker for NSCLC,especially adenocarcinomas andSguamous cell carcinoma.