期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂治疗急性冠脉综合征的研究进展

Progress in Platelet Glycoprotein Ⅱb/Ⅲa Receptor Antagonists Treating Acute Coronary Syndrome
下载PDF
导出
摘要 血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂可阻断纤维蛋白原与血小板糖蛋白Ⅱb/Ⅲa受体的结合,有效地抑制血小板的聚集,在急性冠脉综合征治疗中有重要作用。现就国内外有关研究报道作一综述。 Platelet glycoprotein（GP） Ⅱb/Ⅲa receptor antagonists can effectively block the binding of fibrinogen with glycoprotein Ⅱb/Ⅲa receptor and inhibit platelet aggregation. It plays an important role in the treatment of acute coronary syndrome. The domestic and abroad related studies are reviewed.
作者 陈坚 李平
机构地区 广西医科大学第六附属医院心内科
出处 《现代诊断与治疗》 CAS 2007年第5期284-287,共4页 Modern Diagnosis and Treatment
关键词 糖蛋白 急性冠脉综合征 血栓形成 Glycoprotein Acute coronary syndrome Thrombosis
分类号 R514.4 [医药卫生—内科学]
  • 相关文献

参考文献14

  • 1许俊堂.血小板膜糖蛋白受体拮抗剂在冠状动脉疾病应用的进展[J].中国医药导刊,2000,2(1):44-46. 被引量：3
  • 2葛均波,梁春.急性冠脉综合征(ACS)的诊治进展 冠脉造影法评价急性冠脉综合征发病机制及预后[J].医师进修杂志,2002,25(2):1-3. 被引量：21
  • 3PARAGON investigators.International radomized,controlled trial of lamifiban(a platelet glycoprotein Ⅱb/Ⅲa inhibtor),heparin or both in unstable angina[J].Circulation,1998,97:2386-2395.
  • 4PURSUIT study Investigators.Inhibition of platelet glycoprotein Ⅱb/Ⅲa with eptifibatide in patients with acute coronary syndromes[J].N Engl J Med,1998,339:436-443.
  • 5PRISM PLUS study investigators.Inhibition the platelet glycoprotein Ⅱb/Ⅲa receptor with tirofban in unstable angina and non-Q-wave myocardial infarction[J].N Engl J Med,1998,338:1488-1497.
  • 6Ohman EM,Kleiman NS,Gacioch G,et al.Combined accelerated tissue-plasminogen activator and platelet glycoprotein Ⅱb/Ⅲa aintegrin receptor blockade with integrilin in acute myocardial infarction:result of a radomized,placebo-contrlled,dose-ranging trial[J].Circulation,1997,95:846-854.
  • 7EPIC investigators.Use of a monoclona antibody directed against the platelet glycoprotein Ⅱb/Ⅲa receptor in highrisk coronary angioplasty[J].N Engl J Med,1994,330:956-961.
  • 8EPILOG investigators.Platelet glycoprotein Ⅱb/Ⅲa blockade with abciximab with low-dose heparin during percutaneous coronary revas culariztion[J].N Med,1997,336:1689-1696.
  • 9IMP ACT-Ⅱinvestigators.Randomized placebo-controlled trial of eff ect of eptifibatide on complcation of percutaneous coronary intervention:IMPACT Ⅱ[J].Lancet,1997,349:1422-1428.
  • 10RESTORE investigators.Effects of platelet glycoprotein Ⅱb/Ⅲa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary gioplasty[J].Circulation,1997,96:1445-1453.

二级参考文献24

  • 1[1]Ito H,Tomooka T,Sakai N,et al.Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction[J].Circulation,1992,85(5):1 699-1 705.
  • 2[2]Piana RN,Paik GY,Moscucci M,et al.Incidence and treatment of "no-reflow" after percutaneous coronary intervention[J].Circulation,1994,89(6):2 514-2 518.
  • 3[3]Peerlinck K,De Lepeleire I,Goldberg M,et al.MK-383(L-700,462),a selective nonpeptide platelet glycoprotein Ⅱb/Ⅱa antagonist, Is active in man [J].Circulation, 1993,88(4):1 512-1 517.
  • 4[4]Joseph J,Lynch JR,Jacquelynn J Cook,et al.Nonpeptide Glycoprotein Ⅱb/Ⅱa inhibitors 5 Antithrombotic Effects of MK-0383[J].J Pharmocol Exp Ther,1995,272(1):20-32.
  • 5[5]Davies TA,Drotts D,Weil GJ,et al.Flow cytometric measurements of cytoplasmic calcium changes in human platelets[J].Cytometry, 1988, 9(2):138-142.
  • 6[6]Stenttil SJ,Cunningham M,Hoxie JA.Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry[J].Blood,1987,70(1):307-315.
  • 7The RESTPRE Investigators. Effects of platelet glycoprotein IIb/IIIa blockage with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty. Circulation, 1997,96: 1445.
  • 8Platelet Receptor Inhibition in Ischemic Syndrome Management (PRISM) Study Investigators. A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina. N Engl J Med, 1998,338:1498.
  • 9The PRISM-PLUS Study Investigators. Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. N Engl J Med, 1998,338:1488.
  • 10James C. Bleeding complications of glycoprotein IIb/IIIa receptor inhibitors. Am Heart J, 1999,138:S287.

共引文献59

现代诊断与治疗
2007年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部