替米沙坦对慢性心力衰竭患者神经内分泌激素的影响

The Effects on Neuroendocrine Hormones in Patients with Chronic Heart Failure by Telmisartan

目的探讨替米沙坦对慢性心力衰竭患者神经内分泌激素的影响。方法将96例慢性心力衰竭患者（心功能Ⅱ～Ⅳ级）随机分为两组，分别接受替米沙坦、贝那普利治疗。放射免疫法测定治疗前、治疗3个月后血浆去甲肾上腺素、肾素、血管紧张素Ⅱ、醛固酮及内皮素水平的变化。结果替米沙坦、贝那普利治疗后血浆去甲肾上腺素、内皮素水平均有明显下降（P〈0.01）；贝那普利组血浆肾素、血管紧张素Ⅱ、醛固酮水平无显著变化（P〉0.05）；替米沙坦组血浆肾素、血管紧张素Ⅱ水平有显著下降（P〈0.01），但醛固酮水平无明显变化（P〉0.05）。结论替米沙坦对慢性心力衰竭患者神经内分泌激素只有部分改善作用。

Objective To explore the effects on neuroendocrine hormone in patients with chronic heart failure （CHF） by telmisartan. Methods 96 patients （New York Heart Association class Ⅱ～Ⅳ） were randomly divided into two groups： benazepril group and telmisartan group. The levels of plasma noradrenaline （NE）, renin （R）, angiotensin Ⅱ （Ang Ⅱ）, aldosterone （ALD） and endothelin （ET） were observed before and three months after drugs administration. Result The levels of NE, ET were significantly decreased in both groups （P〈0.01） after drugs were introduced. There were no significant changes in the levels of plasma R, Ang II, ALD（P〉0.05） in benazepril group. In telmisartan group, the levels of R, Ang Ⅱ were significantly decreased （P〈0.01）, but no significant decrease was seen in the level of ALD（P〉0.05）. Conclusion The neurohumoral regulation was only improved to some extent by telmisartan in patients with CHF.