摘要
观察抗肝癌中药消结灵对小鼠移植实体型肝癌和Ｓ１８０肉瘤的抑制作用，超微病理改变，免疫组化定位，研究消结灵的抗癌机理。结果：实验组的肿瘤重量明显减轻，抗肝癌抑制率为４８％～７０％，抗Ｓ１８０肉瘤抑制率为３６％～５１％。在超微病理上，消结灵破坏癌细胞的膜系统，使其裂解崩溃；诱导癌细胞内产生大量溶酶体，致使其溶解变性坏死；激活淋巴细胞增生，免疫组化染色Ｔ淋巴细胞活性增强；枯否氏细胞功能旺盛。
The inhibitory actions of Xiaojieling, an anti cancer Chinese medicine, on the hepatic cancer transplanted in solid form in mouse and the sarcoma S 180 were investigated, and its ultrastructural pathological changes, immunohistochemical localization and anti cancer mechanism were also carried out. The results showed that the weight of cancers in the experimental group reduced remarkably. The inhibitory rate of anti hepatic cancer is 48%～70% and that of sarcoma S180 is 36%～51%. Ultrastructurally, Xiaojieling is observed to be able to destroy the membranous system of cancer cells inducing the cancer cells to produce large quantitis of lysosomes in them. As a result, cancer cells become dissolved, degenerated and then narcotic. At the same time hyperplasia of lymphocytes is activited and the activities of the positive immunohistochemical staining T lymphocytes are also enhanced,promoting vigorously the function of Kupffer cells, secreting the immunoregulating agents and then destroying cancer cell.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1997年第2期126-129,共4页
Journal of China Medical University
关键词
消结灵
肝癌
抑制率
中医药疗法
Xiaojieling
liver cancer
inhibitory rate
immunohistochemical staining
