抗内毒素抗体与抗生素的作用对严重烧伤病人内毒素血症的治疗

Anti LPS antibody and antibiotic treatment in burns

目的：研究抗内毒素抗体与抗生素对严重烧伤并发症——内毒素血症的治疗作用。方法：２９例病人随机分为拮抗内毒素治组和常规治疗组。并在烧伤后不同时相点测定了血浆内毒素，血清ＴＮＦ，和血浆白介素－６（ＩＬ－６）和血浆白介素－８（ＩＬ－８）的含量。结果：抗生素和抗内毒素抗体治疗可明显减少患者血中内毒素水平（Ｐ＜０．０５），同时降低ＩＬ－６，ＩＬ－８和ＴＮＦ血中含量，而单用抗生素治疗对降低血中内毒素水平作用不明显。结论：选择合适的抗生素配合抗内毒素抗体的早期应用，是治疗创伤后内毒素血症及其并发症的有效方法。

Objective: To study treatment and prevention of sepsis which is a common complication of serious burns, anti LPS antibody and different antibiotic treatment were used in this paper. Methods: Twenty nine patients were divied into anti LPS+antibiotic treatment group and antibiotic treatment group. Plasma endotoxin, serum TNF, IL 6 and IL 8 were detected at different time phase after burn. Results: the results show that the antibodies to LPS can decrease the level of LPS, IL 6, IL 8 and TNF obviously, but some antibiotic can′t decrease the level of LPS, IL 6, IL 8 and TNF obviously in blood. Impenem is a weak endotoxin inducer and ceftazidime and ciprofloxacin are stronger endotoxin inducers. Conclusion: The appropriate selection antibiotics with combination use anti LPS antibody in treating sepsis has a considerable influence on cytokine release, i.e. on the body′s inflammatory response.