目安眼膏治疗兔单纯疱疹性角膜炎的研究

The experimental efficacy of Muan ointments(目安眼膏)against HSV-1 in the rabbit eye model

目的观察目安眼膏Ⅰ、Ⅱ号组对单纯疱疹性角膜炎的治疗效果。方法将单纯疱疹性角膜炎模型兔随机分4组,分别用目安眼膏Ⅰ号、Ⅱ号、ACV(无环鸟苷)眼膏和凝胶基质治疗15天,并比较4组兔角膜、结膜、虹膜和角膜混浊病变及超微结构的观察。结果目安眼膏Ⅰ号组较ACV组疗效明显(P<0.05);目安眼膏Ⅱ号组与ACV组疗效差异无显著性(P>0.05),目安眼膏Ⅰ号组比Ⅱ号组疗效显著(P<0.05)。结论目安眼膏Ⅰ号治疗实验性单纯疱疹病毒性角膜炎疗效优于目安眼膏Ⅱ号和无环鸟苷眼膏组。

OBJECTIVE To observe the therapeutic effect of Muan ointment（目安眼膏）ONE and TWO on experimental herpes simplex keratitis（HSK）.METHODS The effected rabbits were divided 4 groups（five animals per treatment group randomly selected）for receiving Muan ointment ONE,Muan ointment TWO,ACV（3% Zovirax ophthalmic ointment）and matrix（placebo）respectively.All eyes were examined the severity of corneal epithelial involvement,conjunctivitis,iritis,and corneal clouding by slit-lamp biomicroscopy and electron microscopy for comparison.RESULTS Compared with ACV group,Muan ointment ONE had significant difference（P〈0.05）and Muan ointment TWO had no significant difference（P〉0.05）.Compared with matrix group,both Muan ointment ONE and TWO groups had significant difference（P〈0.05）.CONCLUSIONS Muan ointment ONE had better effect for HSK than Muan ointment TWO and ACV groups.