脑卒中发生前血液动力学指标的异常变化

Abnormal changes of cerebral vascular hemodynamic parameters before stroke

目的分析和探讨脑卒中发生前脑血管血液动力学指标的异常变化,为卒中高危状态的识别提供参考。方法在基线调查和检测后,收集前瞻性研究人群中随访新发的脑卒中患者(200例)作为试验组,在同一人群中选择基线调查时病程在1年以内的卒中患者(227例)作为对照组,分析和比较两组间脑血管血液动力学指标及其积分值的差异。结果试验组卒中发生前的血液运动学指标普遍低于对照组,血液动力学指标则普遍高于对照组,除最小流速舒张压与临界压的差值外,其他指标两组间有显著的统计学差异(P<0.05)。试验组的血液动力学积分值(51.32±31.37)显著低于对照组(58.44±31.63),P<0.05。结论脑卒中发生前脑血管血液动力学损害程度高于病程1年内的卒中患者,可能是脑卒中的重要预警信号。

Objective To analyze and probe into changes of cerebral vascular hemodynamic indexes（CVHI） before stroke, in order to provide references for identifying individuals in high risk of stroke. Methods 200 newly occurred stroke patients, after baseline investigation and CVHI detection, in a cohort during follow up were defined as experimental group. 227 stroke patients, in the same population and occurred within one year before baseline investigation, were defined as control group. Differences of CVHI and its accumulative scores were compared between two groups. Results kinematics indexes in experimental group were lower than that in control group. While, dynamic indexes were higher than that in controls at large. A part from Vmin and cp, significant differences of all other indexes were found between two groups. Means of the accumulative score in experimental and control group were 51.32±31.37 and 58. 44±31.63, respectively（P〈O.O5）.Conclusions The study indicates that injury degree of cerebrovascular hemodynamic before stroke is rather than these with stroke history within one year. It seems as an important warning indicator.