葡激酶蛋白质工程研究进展

Research development of protein engineering of staphylokinase

近年来,葡激酶的蛋白质工程研究取得了快速进展,主要介绍了葡激酶分子的高级结构、纤溶酶原激活机制、免疫原性的研究进展以及新型葡激酶突变体的分子设计和改造的研究概况。

In recent years, the staphylokinase protein engineering develops very rapidly. The recent research development of staphylokinase, such as the three-dimensional structure, the mechanisms of plasminogen activation, and immunogenicity, are introduced. The molecular design and clinical prospect of recombinant staphylokinase variants with reduced antigenicity and unaltered potency is also discussed.