羌活的化学成分

Chemical Constituents of Notopterygium incisum

目的：研究四川理县羌族地区产我国重要中药材羌活的化学成分,并比较与其他产地该药材之间的成分差别。方法：运用各种分离材料和方法分离羌活根的化学成分,采用波谱技术鉴定其结构。结果：从羌活根的70%丙酮提取物中分离得到12个化合物,经波谱解析分别鉴定为：notoptol（Ⅰ）、羌活醇（Ⅱ）、紫花前胡苷（Ⅲ）、镰叶芹二醇（Ⅳ）、（10E）1,10-heptadecadiene-4,6-diyne-3,8,9-triol（Ⅴ）、10-hydroxyverbenon（Ⅵ）、（＋）-bornylferulate（Ⅶ）、孕甾烯酮醇（Ⅷ）、香草酸（Ⅸ）、香豆酸（Ⅹ）、反式阿魏酸（Ⅺ）和9,12-octadecadienoic acid（Z,Z）-（2,2-dimethyl-1,3-dioxolan-4-yl）methyl ester（Ⅻ）,化合物Ⅰ-Ⅳ、Ⅶ和Ⅷ是其主要成分,化合物Ⅴ-Ⅶ和Ⅹ、Ⅻ为首次从该植物中分离得到。结论：四川理县产羌活的化学成分与其他产地的有所区别。

AIM： To study the chemical constituents of Notopterygium incisum collected from Li county, Siehuan Province, and compare the chemical costituents of Notopterygium incisum between Li county, Sichuan province and other regions. METHODS： Isolating the chemical constituents of the rhizomes of Notoptergium incisum by all kinds of chromatography, and identifying their structures on the basis of spectral analysis. RESULTS： Twelve compounds were isolated from the rhizomes of Notopterygium incisum. Their structures were elucidated as notoptol（ Ⅰ ）, notopterol（ Ⅱ ）, nodakenin（ Ⅲ ）, falcarindiol （ Ⅳ ）, （ 10E）-1, 10-heptadecadiene-4,6-diyne-3,8,9-triol （ Ⅴ ）, 10-hydroxyverbenon（ Ⅵ ）, （ ＋ ）-bornyl ferulate（ Ⅶ ）, pregnenolone（ Ⅷ ）, vanillic acid（ Ⅸ ）, p-coumarin （ Ⅹ ）, trans-ferulic acid（ Ⅺ ） and 9,12-octadecadienoic acid （ Z, Z）-（2, 2-dimethyl-1,3-dioxolan-4-yl） methyl ester（ Ⅻ ）. Among them, compounds Ⅰ - Ⅳ, Ⅶ and Ⅷ are its main constituents; compounds Ⅴ - Ⅶ, Ⅹ and Ⅻ were obtained from this plant for the first time. CONCLUSION： There are some componential differences of Notopterygium incisum between Li county, Sichuan province and other regions.