乳头乳晕角化过度症合并人乳头瘤病毒感染1例报告并文献复习

Hyperkeratosis of Nipple and Areola Complicated with Human Papillomavirus Infection:A Case Report and Literature Review

目的:探讨乳头乳晕角化过度症(HNA)的临床病理特点以及与人乳头瘤病毒(HPV)感染的关系。方法:报告1例HNA合并HPV感染的病例,结合国内外文献资料,对HNA的临床病理特点、诊断、鉴别诊断及治疗进行分析。结果:HNA是一个罕见的良性皮肤疾病。以乳头和(或)乳晕疣状角化过度及黑褐色色素沉着为特点。组织病理示表皮角化过度,棘层肥厚,有乳头瘤样增生,真皮血管周围有灶性淋巴细胞浸润。本例患者合并HPV感染,免疫组化结果示HPV总(+),HPV-6、HPV-11(-)。结论:临床表现及病理形态是HNA确诊的关键。目前还没有有效的治疗方法。

Objective..To explore the clinic and pathological characteristics of Hyperkeratosis of nipple and areola （HNA）and assess the association of HNA and Human papillomavirus （HPV）. Methods;The clinic data of one case of HNA complicated with HPV infection was analyzed and the relevant literatures were reviewed. Results;HNA was a rare and benign condition. Verrucous thickening and pigmentation of the nipple and/or areola were the main features of the condition. The histopathological changes showed hyperkeratosis,acanthosis,papillomatosis,and lymphocytic infiltrate in the dermis. The patient was complicated with HPV infection. The immunohistochernical examination showed the total HPV （＋）,HPV-6 and HPV-11 （-）. Conclusion ：The diagnosis of HNA is mainly dependented on the clinic and pathologic way. There is no specific treatment for this disease now.