期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

吡格列酮联合二甲双胍治疗初诊肥胖青中年2型糖尿病36例分析

下载PDF
导出
摘要 目的:观察二种胰岛素增敏剂(吡格列酮和二甲双胍)联合治疗初诊肥胖年轻2型糖尿病的有效性和安全性。方法:选择符合条件的病例36例,治疗12周,采用随机、开放的方法,观察用药前后的情况并继续治疗观察1 a。结果:(1)12周后FBG、PG2h、HbA1c、BMI有明显下降(P<0.01);(2)无低血糖发生;(3)TC、TG、HDL-L、LDL-C无明显变化(P>0.05)。结论:吡格列酮联合二甲双胍治疗糖尿病是一种安全、有效、合理的治疗方案。
作者 年秀玲 王勇浩
机构地区 河南省漯河市郾城区人民医院内分泌科
出处 《中国误诊学杂志》 CAS 2007年第24期5883-5884,共2页 Chinese Journal of Misdiagnostics
关键词 噻唑烷二酮类/药物疗法 二甲双胍/药物疗法 糖尿病 Ⅱ型/药物疗法
分类号 R587.105.3 [医药卫生—内分泌]
  • 相关文献

参考文献4

  • 1Bautista JL,Bugos C,Dirnberger G,et al.The efficacy and safety of Amarylas Compared to Placebo in mexicam-Amenicans with type 2 diabetes imadequately controlled by exercise and diet alone[J].Diabetes Res Clin Pract,2000,50(suppl 1):s46.
  • 2Walter H,Lubben G.potential roce of oral thiazolidinedione therapy in preserving beta-cell function in type 2 diabetes mellitus[J].Drugs,2005,65(1):1.
  • 3许曼音,陆广华,陈名道,等.糖尿病学[M].2版.上海:科学技术出版社,2004:329-331.
  • 4邹大进,张丽娟.吡格列酮在不同阶段糖尿病治疗中的合理使用[J].实用糖尿病杂志,2005,1(6):56-57. 被引量：3

二级参考文献12

  • 1Walter H,Lubben G.Potential role of oral thiazolidinedione therapy in preserving beta - cell function in type 2 diabetes mellitus.Drugs 2005;65(1):1-13.
  • 2Kipnes MS,Krosnick A,Rendell MS,et al.Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus:a randomized,placebo - controlled study.Am J Med 2001 Jul; 111 (1):10 -17.
  • 3Miyazaki Y,Mahankali A,Matsuda M,et al,Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone.Diabetes Care 2001 Apr; 24 (4):710-719.
  • 4Kawamori R,Matsuhisa M,Kinoshita J,et al.Pioglitazone enhances splanchnic glucose uptake as well as peripheral glucose uptake in non - insulin - dependent diabetes mellitus.AD - 4833 Clamp - OGL Study Group.Diabetes Res Clin Pract 1998 Jul;41(1) :35 -43.
  • 5Kemnitz JW,Elson DF,Roecker EB,et al.Pioglitazone increases insulin sensitivity,reduces blood glucose,insulin,and lipid levels,and lowers blood pressure,in boese,insulin - resistant rhesus monkeys.Diabetes 1994 Feb;43(2) :204- 211.
  • 6Yamaguchi M,Nishimura F,Naruishi H,et al.Thiazolidinedione(pioglitazone)blocks P.gingivalis - and F.nucleatum,but not E.coli,lipopolysaccharide(LPS) - induced interleukin - 6 (IL - 6) production in adipocytes.J Dent Res 2005 Mar; 84 (3):240 - 244.
  • 7Yang WS,Jeng CY,Wu TJ,et al.Synthetic peroxisome proliferator- activated receptor - gamma agonist,rosiglitazone,increases plasma levels of adiponectin in type 2 diabetic patients.Diabetes Care 2002 Feb;25(2) :376 - 380.
  • 8Durbin RJ.Thiazolidinedione therapy in the prevention/delay of type 2 diabetes in patients with impaired glucose tolerance and insulin resistance.Diabetes Obes Metab 2004 Jul;6(4):280- 285.
  • 9Charbonnel BH,Matthews DR,Schemthaner G,et al.A long - term comparison of pioglitazone and gliclazide in patients with Type 2 diabetes mellitus:a randomized,double - blind,parallel - group comparison trial.Diabet Med 2005 Apr;22(4) :399 - 405.
  • 10Ceriello A,Johns D,Widel M,et al.Comparison of effect of piolitazone with metformin or sulfonylurea(monotherapy and combination therapy)on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes.Diabetes Care 2005 Feb;28(2) :266 - 272.

共引文献2

中国误诊学杂志
2007年 第24期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部