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基因印记与胚胎发育

Genetic imprinting and embryonic development
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摘要 基因印记的擦除、建立和维持是正常胚胎发育的基础,这一过程的实现主要有赖于各种DNA甲基转移酶的准确表达和密切合作,多种遗传综合征和胚胎发育缺陷与基因印记异常有关。基因印记对原始生殖细胞胞核全能性、配子成熟、胚胎生长发育、胎盘结构和功能,以及出生后个体的生长发育均有重要意义。 Erasure ,establishment and maintenance of genetic imprinting are indispensable for normal embryonic development. All these processes depend on accurate expression and intimate cooperation of kinds of DNA methyltransferases. Many genetic syndromes and embryo developmental anomalies are caused by abnormality of genetic imprinting. Genetic imprinting is important for the nucleus totipotential of primordial germ cell,maturation of gamete,growth and development of emboryo, structure and function of placenta as well as postnatal growth and development of individuals.
作者 尹丽君 黄荷凤
机构地区 浙江大学医学院附属妇产科医院
出处 《浙江大学学报（医学版）》 CAS CSCD 2007年第5期509-514,共6页 Journal of Zhejiang University(Medical Sciences)
基金 国家973项目子项目(2006CB504004)
关键词 基因印记 DNA甲基化 胚胎发育 DNA修饰甲基酶类 综合征 基因 Genetic imprinting DNA Methylation Embryonic development DNA Modification methylases Syndrome Genes
分类号 R394 [医药卫生—医学遗传学]
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参考文献29

  • 1赵冬梅,金帆,黄荷凤.DNA甲基转移酶与早期胚胎发育[J].浙江大学学报（医学版）,2005,34(3):281-284. 被引量：6
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二级参考文献20

  • 1ROBERTSON K D, UZVOLGYI E,LIANG G,et al.The human DNA methyltransferases (DNMTs) 1,3a and 3b:coordinate mRNA expression in normal tissues and overexpression in tumors [J]. Nucleic Acids Res,1999,27:2291-2298.
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  • 10HOWELL C Y,BESTOR T H,DING F,et al. Genomic imprinting disrupted by a maternal effect mutation in the Dnmtl gene [J]. Cell, 2001,104 :829-838.

共引文献5

浙江大学学报（医学版）
2007年 第5期

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