摘要
目的:探讨种植术后放疗对种植体周围骨密度、种植体骨结合的影响。方法:在16只日本大白兔双侧后肢胫骨同一位置各植入纯钛种植体1枚,2周后随机选取8只作为放疗组,一次性给予60Co15Gy剂量的放疗,余下8只作为对照组不接受放射治疗。通过大体观察、双能X线分析、组织形态学、骨计量学分析及骨-种植体磨片观察等手段,研究术后4、8、16、24周时种植体骨结合情况,应用F检验对实验结果进行统计学分析。结果:术后4周时放疗组种植体周围骨密度比未放疗组降低(P<0.05),种植体骨结合率也较未放疗组降低;术后8周时放疗组种植体周围出现明显的骨结合现象,相当于未放疗组术后4周时的水平;术后16周以后放疗组与未放疗组种植体周围骨密度及种植体骨结合率的差异无显著性。结论:放疗可在一段时间内延缓种植体周围骨的生长,降低骨种植体结合率。
Objective： To evaluate the effect of radiation on osseointegration and the bone density adjacent to implant. Methods： 16 rabbits, implanted with one pieces of pure Ti implants in each side tibias, were divided into 2 groups randomly. Experiment group received radiation after the implant wound healed. All rabbits were sacrificed at 4,8,16,24 weeks postoperationaly. The specimen were observed by gross examination, X-ray, histological examination, ground section of bone with implant, energy dispersion X-ray analysis. Results： At 4 weeks, the bone density adjacent to implant and osseointegration of the simple irradiation group was lower than that of control group（P〈0.05）. At 16 weeks, there were no significant difference between two groups. Osseointegration in experimental groups started at the 8th week, but in control group it started at 4th week. Conclusion： Radiation shows considerable negative effect on osseointegration to implants in a short-term, but it＇s not obvious after 16 weeks.
出处
《口腔颌面外科杂志》
CAS
2007年第3期222-226,共5页
Journal of Oral and Maxillofacial Surgery
基金
厦门科技计划项目(3502820044017)
关键词
放疗
种植体
骨结合
radiation
implant
osseointegration
