自拟退黄散治疗早期新生儿黄疸的临床研究

Tuihuang Powder in the Treatment of Early Neonatal Jaundice:A Clinical Study of Effect

目的观察退黄散治疗新生儿黄疸的疗效,并探讨其可能的作用机制。方法新生儿黄疸216例随机分为两组,观察组采用蓝光+退黄散治疗;对照组采用蓝光治疗。比较两组患儿的退黄时间及胆红素下降情况。结果观察组1周内日均胆红素值及退黄时间与对照组比较,差异有显著性意义(P<0.05)。蓝光照射+退黄散对由不同原因引起新生儿黄疸胆红素下降情况间差异无显著性意义(P>0.05)。结论退黄散对新生儿黄疸有一定治疗作用,可缩短治疗时间,降低血胆红素水平,尤其适用于早期新生儿黄疸治疗及高胆红素血症的预防。

Objective To study the therapeutic effect and the mechanism of Tuihuang powder in the treatment of early neunatal jaundice. Methods 216 newborns with early neunatal jaundice were divided into two groups： observation group （who were given neonate jaundice treatment combined with Tuihuang powder treament） and control group （ who were only given neonate jaundice treatment）. We observed the time of jaundice disappearance and descent of hyperbilitabinemia level. Results Significant difference was observed in the time of jaundice disappearance and descent of hyperbilitabinemia level at daily average within one week between two groups （ P 〈 0.05 ） ; There was no significant difference in descent of hyperbilitabinemia level caused by different origins between them （ P 〉 0. 05 ）. Conclusion Tuihuang powder is an effective drug in the treatment of early neunatal jaundice. It can reduce the hyperbilitabinemia levels, shorten remedial time, and be adapted especially to treatment of early neunatal jaundice and to prevention of hyperbilitabinemia.