血清C-反应蛋白和血黏度联合估计急性冠脉综合征预后的研究

Study of the application of serum C-reactive protein and blood viscosity for predicting prognosis of acute coronary syndrome

目的探讨血清C-反应蛋白(CRP)及血黏度与急性冠脉综合征(ACS)预后的关系。方法CRP浓度的测定采用胶乳法。以CRP≥3.0 mg/L为预测心脏事件的临界值,将ACS患者分成ACSⅠ组(CRP≥3.0 mg/L)和ACSⅡ组(CRP<3.0 mg/L)。同时测定2组患者的血黏度。结果ACSⅠ组、ACSⅡ组CRP浓度及血浆黏度均明显高于正常对照组,ACSⅠ组心脏事件发生率明显高于ACSⅡ组。结论血清CRP水平参与了冠心病的发生,CRP≥3.0 mg/L者发生心脏事件几率高,提示在某种程度上血清CRP水平判断ACS预后较血黏度更有价值。CRP≥3.0 mg/L可作为判断国人ACS预后的界限值以便预测。

Objective It is to explore the relationship of serum C-reactive protein （CRP） and blood viscosity with prognosis of acute coronary syndrome （ACS）. Methods The content of CRP was determined with latex method. The patients with ACS were divided into ACS group I （CRP≥3.0 mg/L） and ACS group II （CRP〈 3.0 mg/L） according to the critical value of CRP≥3.0 mg/L for predicting heart incidence. Then blood viscosity of the two groups was measured. Results The contents of CRP and blood viscosity in ACS group I and ACS group II were both significantly higher than that in normal control group. The incidence rate of heart incidence in ACS group I was obviously higher than that in ACS group II. Conclusion The level of Serum CRP took a part in the occurrence of coronary heart disease, and the ones with CRP≥3.0 mg/L have high probability of heart incidence. It shows that serum CRP has more value for predicting prognosis of ACS than blood viscosity. CRP≥3.0 mg/L can be used as the critical value for diagnosing prognosis of ACS.